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Advanced Methods in Twin Studies

  • Jaakko Kaprio
  • Karri Silventoinen
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 713)

Abstract

While twin studies have been used to estimate the heritability of different traits and disorders since the beginning of the twentieth century, statistical developments over the past 20 years and more extensive and systematic data collection have greatly expanded the scope of twin studies. This chapter reviews selected possibilities of twin study designs to address specific hypotheses regarding the role of both genetic and environmental factors in the development of traits and diseases. In addition to modelling latent genetic influences, current models permit inclusion of information on specific genetic variants, measured environmental factors and their interactive effects. Examples from studies of anthropometric traits are used to illustrate such approaches.

Key words

Quantitative genetics Twins Models Behaviour genetics Obesity Longitudinal studies 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Jaakko Kaprio
    • 1
  • Karri Silventoinen
    • 2
  1. 1.Department of Public Health and Institute of Molecular MedicineUniversity of Helsinki & National Institute for Health and WelfareHelsinkiFinland
  2. 2.Departments of Sociology and Public HealthUniversity of HelsinkiHelsinkiFinland

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