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Gene-Based Approaches in the Study of Pathological Pain

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Analgesia

Part of the book series: Methods in Molecular Biology ((MIMB,volume 617))

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Abstract

Chronic pathological pain is characterized by extensive plasticity of the systems involved in pain signal transmission and modulation and tissue remodeling in several CNS structures. These long-lasting alterations are mediated by, or associated with, changes in the production of key molecules of nociceptive processing. Gene-based approaches offer the unique possibility of using local or even cell-type specific interventions to correct the abnormal production of some of these proteins, modulate the activity of signal transduction pathways, or overproduce various therapeutic secreted proteins. We showed that certain viral-derived vectors are particularly suitable for mediating gene transfer highly preferential for instance into the primary sensory neurons or into the spinal cord glial cells that represent particularly pertinent targets in the search for new therapeutic strategies of pathological pain.

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Acknowledgments

This work was supported by grants from INSERM, Université Pierre et Marie Curie-Paris 6, Institut UPSA de la Douleur and Institut pour la Recherche sur la Moelle épinière et l’Encéphale.

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Authors and Affiliations

  1. Faculty of Medicine Pitié-Salpêtrière, Brain and Spinal Cord Research Institute, INSERM UMRS 975, Pain Group, Paris, France

    Elisa Dominguez

  2. Pitié-Salpêtrière Hospital, Brain and Spinal Cord Research Institute, INSERM UMRS 975, Neuron-Glia Interactions Group, Paris, France

    Alice Meunier & Michel Pohl

Authors
  1. Elisa Dominguez
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  2. Alice Meunier
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  3. Michel Pohl
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Corresponding author

Correspondence to Michel Pohl .

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Editors and Affiliations

  1. Dept. Pathology, Monmouth Medical Center, Second Ave. 300, Long Branch, 07750, USA

    Arpad Szallasi

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Dominguez, E., Meunier, A., Pohl, M. (2010). Gene-Based Approaches in the Study of Pathological Pain. In: Szallasi, A. (eds) Analgesia. Methods in Molecular Biology, vol 617. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-323-7_22

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  • DOI: https://doi.org/10.1007/978-1-60327-323-7_22

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-322-0

  • Online ISBN: 978-1-60327-323-7

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