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Tour de Herpes: Cycling Through the Life and Biology of HSV-1

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Herpes Simplex Virus

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2060))

Abstract

Herpes simplex virus type 1 (HSV-1) is a prevalent and important human pathogen that has been studied in a wide variety of contexts. This book provides protocols currently in use in leading laboratories in many fields of HSV-1 research. This introductory chapter gives a brief overview of HSV-1 biology and life cycle, covering basic aspects of virus structure, the prevalence of and diseases caused by the virus, replication in cultured cells, viral latency, antiviral defenses, and the mechanisms that the virus uses to counteract these defenses.

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Acknowledgments

This work was funded by the UK Medical Research Council (to R.D.E.) and the Australian National Health and Medical Research Council (to R.J.D.). An Australian Government Research Training Program stipend was awarded to C.E.D. The authors are very grateful for the TEM image provided by Dr. Monica Miranda-Saksena that is presented in Fig. 1a.

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  1. Russell J. Diefenbach

    Present address: Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia

Authors and Affiliations

  1. Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia

    Christopher E. Denes & Russell J. Diefenbach

  2. MRC - University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK

    Roger D. Everett

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  1. Christopher E. Denes
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  1. Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia

    Russell J. Diefenbach

  2. Institute of Virology, University of Zurich, Zürich, Switzerland

    Cornel Fraefel

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Denes, C.E., Everett, R.D., Diefenbach, R.J. (2020). Tour de Herpes: Cycling Through the Life and Biology of HSV-1. In: Diefenbach, R., Fraefel, C. (eds) Herpes Simplex Virus . Methods in Molecular Biology, vol 2060. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9814-2_1

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