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Morphological Brain Alterations in Patients with Obsessive–Compulsive Disorder

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Brain Morphometry

Part of the book series: Neuromethods ((NM,volume 136))

Abstract

Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors that are experienced as unwanted. Structural magnetic resonance imaging (MRI) studies, using different techniques such as manual tracing, voxel-based morphometry (VBM), cortical thickness analysis, and diffusion tensor imaging (DTI), investigating brain abnormalities in OCD patients have been numerous. These studies have implicated the cortico-striato-thalamo-cortical (CSTC) circuit in the pathophysiology of the disorder. However, results have not always been consistent. Variability in study results may partially be explained by small sample sizes, clinical heterogeneity between patient samples, and methodological differences between studies.

In this chapter, we review the most consistent findings on morphological brain alterations in patients with OCD, and we discuss the relationship within the implicated networks. The reviewed literature shows that the pathophysiology of OCD cannot be explained by alterations in function and structure of the classical CSTC regions exclusively and emphasizes the importance of other fronto-limbic and frontoparietal areas as well as the cerebellum. Moreover, these findings support the notion that the brain alterations found in OCD patients are represented at the network level rather than discrete brain regions. The widespread abnormalities across several different regions and circuits, and their interconnectivity, fit with the complex phenomenology of OCD, which includes different emotional, cognitive, and behavioral domains. A life span perspective on the structural brain abnormalities in OCD is warranted since variation in developmental stage, symptom profile, and disease stage seems to underlie variation in structural abnormalities.

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References

  1. Kessler RC, Pethukhova M, Sampson NA, Zaslavsky AM, Wittchen HU (2012) Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res 21:169–184

    Article  PubMed  PubMed Central  Google Scholar 

  2. Ruscio AM, Stein DJ, Chiu WT, Kessler RC (2010) The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry 15:53–63

    Article  CAS  PubMed  Google Scholar 

  3. Subramaniam M, Abdin E, Vaingankar JA, Chong SA (2012) Obsessive-compulsive disorder: prevalence, correlates, help-seeking and quality of life in a multiracial Asian population. Soc Psychiatry Psychiatr Epidemiol 47:2035–2043

    Article  PubMed  Google Scholar 

  4. American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, vol 4. American Psychiatric Association, Washington, DC

    Google Scholar 

  5. Nestadt G et al (2000) A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 57:358–363

    Article  CAS  PubMed  Google Scholar 

  6. Stewart SE et al (2004) Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr Scand 110:4–13

    Article  CAS  PubMed  Google Scholar 

  7. Mataix-Cols D, Conceicao do Rosario-Campos M, Leckman JF (2005) A multidimensional model of obsessive-compulsive disorder. Am J Psychiatry 162:228–238

    Article  PubMed  Google Scholar 

  8. Mataix-Cols D et al (2002) Symptom stability in adult obsessive-compulsive disorder: data from a naturalistic two-year follow-up study. Am J Psychiatry 159:263–268

    Article  PubMed  Google Scholar 

  9. Rufer M, Grothusen A, Maß R, Peter H, Hand I (2005) Temporal stability of symptom dimensions in adult patients with obsessive-compulsive disorder. J Affect Disord 88:99–102

    Article  PubMed  Google Scholar 

  10. Matsunaga H et al (2008) Symptom structure in Japanese patients with obsessive-compulsive disorder. Am J Psychiatry 165:251–253

    Article  PubMed  Google Scholar 

  11. Bloch MH, Landeros-Weisenberger A, Rosario MC, Pittenger C, Leckman JF (2008) Meta-analysis of the symptom structure of obsessive-compulsive disorder. Am J Psychiatry 165:1532–1542

    Article  PubMed  PubMed Central  Google Scholar 

  12. Pallanti S, Grassi G, Sarrecchia ED, Cantisani A, Pellegrini M (2011) Obsessive-compulsive disorder comorbidity: clinical assessment and therapeutic implications. Front Psych 2:1–11

    Google Scholar 

  13. Hasler G et al (2005) Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity. Psychiatry Res 135:121–132

    Article  PubMed  Google Scholar 

  14. An SK et al (2009) To discard or not to discard: the neural basis of hoarding symptoms in obsessive-compulsive disorder. Mol Psychiatry 14:318–331

    Article  CAS  PubMed  Google Scholar 

  15. Lawrence NS et al (2007) Neural responses to facial expressions of disgust but not fear are modulated by washing symptoms in OCD. Biol Psychiatry 61:1072–1080

    Article  PubMed  Google Scholar 

  16. Mataix-Cols D et al (2004) Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiatry 61:564–576

    Article  PubMed  Google Scholar 

  17. van den Heuvel OA et al (2009) The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems. Brain 132:853–868

    Article  PubMed  Google Scholar 

  18. Hasler G et al (2007) Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD collaborative genetics study. Biol Psychiatry 61:617–625

    Article  CAS  PubMed  Google Scholar 

  19. Pinto A et al (2007) Taboo thoughts and doubt/checking: a refinement of the factor structure for obsessive-compulsive disorder symptoms. Psychiatry Res 151:255–258

    Article  PubMed  PubMed Central  Google Scholar 

  20. Stewart SE et al (2007) Principal components analysis of obsessive-compulsive disorder symptoms in children and adolescents. Biol Psychiatry 61:285–291

    Article  PubMed  Google Scholar 

  21. Cummings JL, Cunningham K (1992) Obsessive-compulsive disorder in Huntington’s disease. Biol Psychiatry 31:263–270

    Article  CAS  PubMed  Google Scholar 

  22. Swedo E et al (1989) High prevalence of obsessive-compulsive symptoms in patients with Sydenham’s symptoms. Am J Psychiatry 146:246–249

    Article  CAS  PubMed  Google Scholar 

  23. Laplane D et al (1989) Obsessive-compulsive and other behavioural changes with bilateral basal ganglia lesions. Brain 112:699–725

    Article  PubMed  Google Scholar 

  24. Eslinger PJ, Damasio AR (1985) Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology 35:1731

    Article  CAS  PubMed  Google Scholar 

  25. Alexander GE (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357–381

    Article  CAS  PubMed  Google Scholar 

  26. Cummings J (1993) Frontal-subcortical circuits and human behavior. Arch Neurol 50:873–880

    Article  CAS  PubMed  Google Scholar 

  27. Groenewegen HJ, Uylings HB (2000) The prefrontal cortex and the integration of sensory, limbic and autonomic information. Prog Brain Res 126:3–28

    Article  CAS  PubMed  Google Scholar 

  28. Graybiel AM, Rauch SL (2000) Toward a neurobiology of obsessive-compulsive disorder. Neuron 28:343–347

    Article  CAS  PubMed  Google Scholar 

  29. Mataix-Cols D, van den Heuvel OA (2006) Common and distinct neural correlates of obsessive-compulsive and related disorders. Psychiatr Clin North Am 29:391–410, viii

    Article  PubMed  Google Scholar 

  30. Menzies L et al (2008) Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev 32:525–549

    Article  PubMed  Google Scholar 

  31. Milad MR, Rauch SL (2012) Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways. Trends Cogn Sci 16:43–51

    Article  PubMed  Google Scholar 

  32. van den Heuvel OA et al (2016) Brain circuitry of compulsivity. Eur Neuropsychopharmacol 26:810–827

    Article  PubMed  CAS  Google Scholar 

  33. Behar D et al (1984) Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder. Am J Psychiatry 141:363–369

    Article  CAS  PubMed  Google Scholar 

  34. Insel TR, Donnelly EF, Lalakea ML, Alterman IS, Murphy DL (1983) Neurological and neuropsychological studies of patients with obsessive–compulsive disorder. Biol Psychiatry 18:741–751

    CAS  PubMed  Google Scholar 

  35. Hutton C, Draganski B, Ashburner J, Weiskopf N (2009) A comparison between voxel-based cortical thickness and voxel-based morphometry in normal aging. NeuroImage 48:371–380

    Article  PubMed  PubMed Central  Google Scholar 

  36. Voets NL et al (2008) Evidence for abnormalities of cortical development in adolescent-onset schizophrenia. NeuroImage 43:665–675

    Article  PubMed  Google Scholar 

  37. Frye RE et al (2010) Surface area accounts for the relation of gray matter volume to reading-related skills and history of dyslexia. Cereb Cortex 20:2625–2635

    Article  PubMed  PubMed Central  Google Scholar 

  38. Rosenberg DR, Keshavan MS (1998) Toward a neurodevelopmental model of obsessive-compulsive disorder. Biol Psychiatry 43:623–640

    Article  CAS  PubMed  Google Scholar 

  39. Fontenelle LF et al (2009) Is there evidence of brain white-matter abnormalities in obsessive-compulsive disorder?: a narrative review. Top Magn Reson Imaging 20:291–298

    Article  PubMed  Google Scholar 

  40. Douzenis A et al (2009) Obsessive-compulsive disorder associated with parietal white matter multiple sclerosis plaques. World J Biol Psychiatry 10:956–960

    Article  PubMed  Google Scholar 

  41. Pujol J et al (2004) Mapping structural brain alterations in obsessive-compulsive disorder. Arch Gen Psychiatry 61:720–730

    Article  PubMed  Google Scholar 

  42. Gilbert AR et al (2008) Brain structure and symptom dimension relationships in obsessive-compulsive disorder: a voxel-based morphometry study. J Affect Disord 109:117–126

    Article  PubMed  Google Scholar 

  43. Szeszko PR et al (2008) Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry study. Am J Psychiatry 165:1299–1307

    Article  PubMed  Google Scholar 

  44. Yoo SY et al (2008) Voxel-based morphometry study of gray matter abnormalities in obsessive-compulsive disorder. J Korean Med Sci 23:24–30

    Article  PubMed  PubMed Central  Google Scholar 

  45. Zarei M et al (2011) Changes in gray matter volume and white matter microstructure in adolescents with obsessive-compulsive disorder. Biol Psychiatry 70:1083–1090

    Article  PubMed  Google Scholar 

  46. Peng Z et al (2012) Brain structural abnormalities in obsessive-compulsive disorder: converging evidence from white matter and grey matter. Asian J Psychiatr 5:290–296

    Article  PubMed  Google Scholar 

  47. Radua J, Mataix-Cols D (2009) Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder. Br J Psychiatry 195:393–402

    Article  PubMed  Google Scholar 

  48. Radua J, van den Heuvel OA, Surguladze S, Mataix-Cols D (2010) Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders. Arch Gen Psychiatry 67:701–711

    Article  PubMed  Google Scholar 

  49. Rotge J-Y et al (2010) Gray matter alterations in obsessive-compulsive disorder: an anatomic likelihood estimation meta-analysis. Neuropsychopharmacology 35:686–691

    Article  CAS  PubMed  Google Scholar 

  50. Boedhoe PSW et al (2017) Distinct subcortical volume alterations in pediatric and adult OCD: a worldwide meta- and mega-analysis. Am J Psychiatry 174:60–70

    Article  PubMed  Google Scholar 

  51. de Wit SJ et al (2014) Multicenter voxel-based morphometry mega-analysis of structural brain scans in obsessive-compulsive disorder. Am J Psychiatry 171:340–349

    Article  PubMed  Google Scholar 

  52. Rosenberg DR et al (1997) Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder. Arch Gen Psychiatry 54:824–830

    Article  CAS  PubMed  Google Scholar 

  53. Szeszko PR et al (2004) Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder. Am J Psychiatry 161:1049–1056

    Article  PubMed  Google Scholar 

  54. Carmona S et al (2007) Pediatric OCD structural brain deficits in conflict monitoring circuits: a voxel-based morphometry study. Neurosci Lett 421:218–223

    Article  CAS  PubMed  Google Scholar 

  55. van Essen DC (1997) A tension-based theory of morphogenesis and compact wiring in the central nervous system. Nature 385:313–318

    Article  PubMed  Google Scholar 

  56. Levitt JJ et al (2004) Shape of caudate nucleus and its cognitive correlates in neuroleptic-naive schizotypal personality disorder. Biol Psychiatry 55:177–184

    Article  PubMed  PubMed Central  Google Scholar 

  57. Choi JS et al (2007) Shape deformity of the corpus striatum in obsessive-compulsive disorder. Psychiatry Res 155:257–264

    Article  PubMed  Google Scholar 

  58. Shaw P et al (2015) Subcortical and cortical morphological anomalies as an endophenotype in obsessive-compulsive disorder. Mol Psychiatry 20:224–231

    Article  CAS  PubMed  Google Scholar 

  59. Atmaca M et al (2006) Volumetric MRI assessment of brain regions in patients with refractory obsessive-compulsive disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 30:1051–1057

    Article  Google Scholar 

  60. Atmaca M, Yildirim H, Ozdemir H, Tezcan E, Kursad Poyraz A (2007) Volumetric MRI study of key brain regions implicated in obsessive-compulsive disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 31:46–52

    Article  Google Scholar 

  61. Gilbert R et al (2000) Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine. Arch Gen Psychiatry 57:449–456

    Article  CAS  PubMed  Google Scholar 

  62. Kang D-H et al (2008) Thalamus surface shape deformity in obsessive-compulsive disorder and schizophrenia. Neuroreport 19:609–613

    Article  PubMed  Google Scholar 

  63. Rotge J-Y et al (2009) Meta-analysis of brain volume changes in obsessive-compulsive disorder. Biol Psychiatry 65:75–83

    Article  PubMed  Google Scholar 

  64. Kim J-J et al (2001) Grey matter abnormalities in obsessive—compulsive disorder: statistical parametric mapping of segmented magnetic resonance images. Br J Psychiatry 179:330–334

    Article  CAS  PubMed  Google Scholar 

  65. Christian CJ et al (2008) Gray matter structural alterations in obsessive-compulsive disorder: relationship to neuropsychological functions. Psychiatry Res 164:123–131

    Article  PubMed  PubMed Central  Google Scholar 

  66. Valente AA et al (2005) Regional gray matter abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study. Biol Psychiatry 58:479–487

    Article  PubMed  Google Scholar 

  67. Shin Y-W et al (2007) Cortical thinning in obsessive compulsive disorder. Hum Brain Mapp 28:1128–1135

    Article  PubMed  Google Scholar 

  68. Kuhn S et al (2013) Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder. Cortex 49:2178–2185

    Article  PubMed  Google Scholar 

  69. Venkatasubramanian G et al (2012) Comprehensive evaluation of cortical structure abnormalities in drug-naïve, adult patients with obsessive-compulsive disorder: a surface-based morphometry study. J Psychiatr Res 46:1161–1168

    Article  PubMed  Google Scholar 

  70. Fullana MA et al (2014) Brain regions related to fear extinction in obsessive-compulsive disorder and its relation to exposure therapy outcome: a morphometric study. Psychol Med 44:845–856

    Article  CAS  PubMed  Google Scholar 

  71. Huyser C et al (2013) Increased orbital frontal gray matter volume after cognitive behavioural therapy in paediatric obsessive compulsive disorder. World J Biol Psychiatry 14:319–331

    Article  PubMed  Google Scholar 

  72. Huyser C et al (2014) A longitudinal VBM study in paediatric obsessive-compulsive disorder at 2-year follow-up after cognitive behavioural therapy. World J Biol Psychiatry 15:443–452

    Article  PubMed  Google Scholar 

  73. Bush G, Luu P, Posner M (2000) Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4:215–222

    Article  CAS  PubMed  Google Scholar 

  74. Aouizerate B et al (2004) Pathophysiology of obsessive-compulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology. Prog Neurobiol 72:195–221

    Article  PubMed  Google Scholar 

  75. Ochsner KN, Gross JJ (2005) The cognitive control of emotion. Trends Cogn Sci 9:242–249

    Article  PubMed  Google Scholar 

  76. van Tol M et al (2010) Regional brain volume in depression and anxiety disorders. Arch Gen Psychiatry 67:1002–1011

    Article  PubMed  Google Scholar 

  77. Goodkind M et al (2015) Identification of a common neurobiological substrate for mental illness. JAMA Psychiat 72:305–315

    Article  Google Scholar 

  78. Ziegler G et al (2012) Brain structural trajectories over the adult lifespan. Hum Brain Mapp 33:2377–2389

    Article  PubMed  Google Scholar 

  79. Tops M, Boksem MA (2011) Potential role of the inferior frontal gyrus and anterior insula in cognitive control, brain rhythms, and event-related potentials. Front Psychol 2:1–14

    Article  Google Scholar 

  80. Corbetta M, Shulman GL (2002) Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci 3:201–215

    Article  CAS  PubMed  Google Scholar 

  81. Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ (2004) Neural systems supporting interoceptive awareness. Nat Neurosci 7:189–195

    Article  CAS  PubMed  Google Scholar 

  82. Calder AJ, Lawrence AD, Young AW (2001) Neuropsychology of fear and loathing. Nat Rev Neurosci 2:352–363

    Article  CAS  PubMed  Google Scholar 

  83. Paulus MP, Stein MB (2010) Interoception in anxiety and depression. Brain Struct Funct 214:451–463

    Article  PubMed  PubMed Central  Google Scholar 

  84. de Wit SJ et al (2012) Presupplementary motor area hyperactivity during response inhibition: a candidate endophenotype of obsessive-compulsive disorder. Am J Psychiatry 169:1100–1108

    Article  PubMed  Google Scholar 

  85. Selles RR, Storch EA, Lewin AB (2014) Variations in symptom prevalence and clinical correlates in younger versus older youth with obsessive–compulsive disorder. Child Psychiatry Hum Dev 45:666–674

    Article  PubMed  Google Scholar 

  86. Schmaal L et al (2016) Subcortical brain alterations in major depressive disorder: findings from the ENIGMA major depressive disorder working group. Mol Psychiatry 21:806–812

    Article  CAS  PubMed  Google Scholar 

  87. van Erp TGM et al (2016) Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry 21:547–553

    Article  PubMed  Google Scholar 

  88. Hibar DP et al (2016) Subcortical volumetric abnormalities in bipolar disorder. Mol Psychiatry 21:1710–1716

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Fouche J-P, du Plessis S, Hattingh C, et al (2017) Cortical thickness in obsessive-compulsive disorder: multisite mega-analysis of 780 brain scans from six centres. Br J Psychiatry 210:67–74

    Google Scholar 

  90. Hong SB et al (2007) Hippocampal shape deformity analysis in obsessive-compulsive disorder. Eur Arch Psychiatry Clin Neurosci 257:185–190

    Article  PubMed  Google Scholar 

  91. Fischl B et al (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33:341–355

    Article  CAS  PubMed  Google Scholar 

  92. Grieve SM, Clark CR, Williams LM, Peduto AJ, Gordon E (2005) Preservation of limbic and paralimbic structures in aging. Hum Brain Mapp 25:391–401

    Article  PubMed  Google Scholar 

  93. Kassem MS et al (2013) Stress-induced grey matter loss determined by MRI is primarily due to loss of dendrites and their synapses. Mol Neurobiol 47:645–661

    Article  CAS  PubMed  Google Scholar 

  94. Harrison BJ et al (2009) Altered corticostriatal functional connectivity in obsessive-compulsive disorder. Arch Gen Psychiatry 66:1189–1200

    Article  PubMed  Google Scholar 

  95. Massana G et al (2003) Parahippocampal gray matter density in panic disorder: a voxel-based morphometric study. Am J Psychiatry 160:566–568

    Article  PubMed  Google Scholar 

  96. Massana G et al (2003) Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging. NeuroImage 19:80–90

    Article  PubMed  Google Scholar 

  97. Middleton FA, Strick PL (2000) Basal ganglia output and cognition: evidence from anatomical, behavioral, and clinical studies. Brain Cogn 42:183–200

    Article  CAS  PubMed  Google Scholar 

  98. Le Bihan D et al (2001) Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging 13:534–546

    Article  PubMed  Google Scholar 

  99. Fan Q et al (2012) Abnormalities of white matter microstructure in unmedicated obsessive-compulsive disorder and changes after medication. PLoS One 7(4):e35889

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Radua J et al (2014) Multimodal voxel-based meta-analysis of white matter abnormalities in obsessive–compulsive disorder. Neuropsychopharmacology 39:1547–1557

    Article  PubMed  PubMed Central  Google Scholar 

  101. Benedetti F et al (2013) Widespread changes of white matter microstructure in obsessive-compulsive disorder: effect of drug status. Eur Neuropsychopharmacol 23:581–593

    Article  CAS  PubMed  Google Scholar 

  102. Yoo SY et al (2007) White matter abnormalities in drug-naïve patients with obsessive-compulsive disorder: a diffusion tensor study before and after citalopram treatment. Acta Psychiatr Scand 116:211–219

    Article  CAS  PubMed  Google Scholar 

  103. Peters BD et al (2012) White matter development in adolescence: diffusion tensor imaging and meta-analytic results. Schizophr Bull 38:1308–1317

    Article  PubMed  PubMed Central  Google Scholar 

  104. Schmahmann JD et al (2007) Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography. Brain 130:630–653

    Article  PubMed  Google Scholar 

  105. Piras F, Piras F, Caltagirone C, Spalletta G (2013) Brain circuitries of obsessive compulsive disorder: a systematic review and meta-analysis of diffusion tensor imaging studies. Neurosci Biobehav Rev 37:2856–2877

    Article  PubMed  Google Scholar 

  106. Koch K, Reeß TJ, Rus OG, Zimmer C, Zaudig M (2014) Diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD): a review. J Psychiatr Res 54:26–35

    Article  PubMed  Google Scholar 

  107. Gruner P et al (2012) White matter abnormalities in pediatric obsessive-compulsive disorder. Neuropsychopharmacology 37:2730–2739

    Article  PubMed  PubMed Central  Google Scholar 

  108. Fontenelle LF, Mendlowicz MV, Marques C, Versiani M (2003) Early- and late-onset obsessive-compulsive disorder in adult patients: an exploratory clinical and therapeutic study. J Psychiatr Res 37:127–133

    Article  PubMed  Google Scholar 

  109. Koch K et al (2012) White matter structure and symptom dimensions in obsessive-compulsive disorder. J Psychiatr Res 46:264–270

    Article  PubMed  Google Scholar 

  110. Catani M, Howard RJ, Pajevic S, Jones DK (2002) Virtual in vivo interactive dissection of white matter fasciculi in the human brain. NeuroImage 17:77–94

    Article  PubMed  Google Scholar 

  111. Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PCM, Mori S (2004) Fiber tract-based atlas of human white matter anatomy. Radiology 230:77–87

    Article  PubMed  Google Scholar 

  112. Devinsky O, Morrell MJ, Vogt BA (1995) Contributions of anterior cingulate cortex to behaviour. Brain 118:279–306

    Article  PubMed  Google Scholar 

  113. Schlösser RGM et al (2010) Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modeling. Hum Brain Mapp 31:1834–1850

    Article  PubMed  Google Scholar 

  114. Bernal B, Altman N (2010) The connectivity of the superior longitudinal fasciculus: a tractography DTI study. Magn Reson Imaging 28:217–225

    Article  PubMed  Google Scholar 

  115. Hoeft F et al (2007) More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome. J Neurosci 27:11960–11965

    Article  CAS  PubMed  Google Scholar 

  116. Karlsgodt KH et al (2008) Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia. Biol Psychiatry 63:512–518

    Article  PubMed  Google Scholar 

  117. Madhavan KM, McQueeny T, Howe SR, Shear P, Szaflarski J (2014) Superior longitudinal fasciculus and language functioning in healthy aging. Brain Res 1562:11–22

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  118. Murphy ML, Frodl T (2011) Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression. Biol Mood Anxiety Disord 1(1):3

    Article  PubMed  PubMed Central  Google Scholar 

  119. Makris N et al (2005) Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study. Cereb Cortex 15:854–869

    Article  PubMed  Google Scholar 

  120. Matsumoto R et al (2010) Reduced gray matter volume of dorsal cingulate cortex in patients with obsessive-compulsive disorder: a voxel-based morphometric study. Psychiatry Clin Neurosci 64:541–547

    Article  PubMed  Google Scholar 

  121. Piras F et al (2015) Widespread structural brain changes in OCD: a systematic review of voxel-based morphometry studies. Cortex 62:89–108

    Article  PubMed  Google Scholar 

  122. Togao O et al (2010) Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study. Psychiatry Res 184:29–37

    Article  PubMed  Google Scholar 

  123. Ha TH et al (2009) White matter alterations in male patients with obsessive-compulsive disorder. Neuroreport 20:735–739

    Article  PubMed  Google Scholar 

  124. Subira M et al (2015) Structural covariance of neostriatal and limbic regions in patients with obsessive-compulsive disorder. J Psychiatry Neurosci 41:115–123

    Article  PubMed Central  Google Scholar 

  125. Pauls DL, Abramovitch A, Rauch SL, Geller DA (2014) Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective. Nat Rev Neurosci 15:410–424

    Google Scholar 

  126. Menzies L et al (2008) White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives. Am J Psychiatry 165:1308–1315

    Article  PubMed  Google Scholar 

  127. den Braber A et al (2010) Brain activation during cognitive planning in twins discordant or concordant for obsessive-compulsive symptoms. Brain 133:3123–3140

    Article  Google Scholar 

  128. den Braber A et al (2011) White matter differences in monozygotic twins discordant or concordant for obsessive-compulsive symptoms: a combined diffusion tensor imaging/voxel-based morphometry study. Biol Psychiatry 70:969–977

    Article  Google Scholar 

  129. den Braber A et al (2012) Brain activation during response interference in twins discordant or concordant for obsessive compulsive symptoms. Twin Res Hum Genet 15:372–383

    Article  Google Scholar 

  130. Thompson PM et al (2014) The ENIGMA consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav 8:153–182

    PubMed  PubMed Central  Google Scholar 

  131. Hibar DP et al (2015) Common genetic variants influence human subcortical brain structures. Nature 520:224–229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. Arnsten AFT, Rubia K (2012) Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders. J Am Acad Child Adolesc Psychiatry 51:356–367

    Article  PubMed  Google Scholar 

  133. Lázaro L et al (2009) Brain changes in children and adolescents with obsessive-compulsive disorder before and after treatment: a voxel-based morphometric MRI study. Psychiatry Res 172:140–146

    Article  PubMed  Google Scholar 

  134. Hoexter MQ et al (2012) Gray matter volumes in obsessive-compulsive disorder before and after fluoxetine or cognitive-behavior therapy: a randomized clinical trial. Neuropsychopharmacology 37:734–745

    Article  CAS  PubMed  Google Scholar 

  135. Rosenberg DR, Benazon NR, Gilbert A, Sullivan A, Moore GJ (2000) Thalamic volume in pediatric obsessive-compulsive disorder patients before and after cognitive behavioral therapy. Biol Psychiatry 48:294–300

    Article  CAS  PubMed  Google Scholar 

  136. Hoexter MQ et al (2013) Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive-compulsive disorder. Eur Neuropsychopharmacol 23:569–580

    Article  CAS  PubMed  Google Scholar 

  137. Hashimoto N et al (2014) Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry. Neuropsychiatr Dis Treat 10:1987–1996

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands

    Premika S. W. Boedhoe & Odile A. van den Heuvel

  2. Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands

    Premika S. W. Boedhoe & Odile A. van den Heuvel

  3. Amsterdam Neuroscience, Amsterdam, The Netherlands

    Premika S. W. Boedhoe & Odile A. van den Heuvel

Authors
  1. Premika S. W. Boedhoe
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  2. Odile A. van den Heuvel
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Correspondence to Odile A. van den Heuvel .

Editor information

Editors and Affiliations

  1. IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy

    Gianfranco Spalletta

  2. Division of Neuropsychiatry Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA

    Fabrizio Piras

  3. IMT School for Advanced Studies–Lucca, Lucca, Italy

    Tommaso Gili

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Boedhoe, P.S.W., van den Heuvel, O.A. (2018). Morphological Brain Alterations in Patients with Obsessive–Compulsive Disorder. In: Spalletta, G., Piras, F., Gili, T. (eds) Brain Morphometry. Neuromethods, vol 136. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7647-8_23

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  • DOI: https://doi.org/10.1007/978-1-4939-7647-8_23

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7645-4

  • Online ISBN: 978-1-4939-7647-8

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