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MRI in the Study of Animal Models of Neurodegenerative Diseases

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Preclinical MRI

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1718))

Abstract

Magnetic Resonance Imaging (MRI) is an important tool to study various animal models of degenerative diseases. This chapter describes routine protocols of T 1-, T 2-, and T 2*-weighted and diffusion-weighted MRI for rodent brain and spinal cord. These protocols can be used to measure atrophy, axonal and myelin injury and changes in white matter connectivity.

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Acknowledgements

N.K. thanked the Queensland Government and Australian Federal Government for funding and operational support of the 16.4T NMR spectrometer through the QLD NMR Network (QNN) and the National Imaging Facility (NIF).

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Authors and Affiliations

  1. Centre for Advanced Imaging, The University of Queensland, St. Lucia, QLD, Australia

    Nyoman D. Kurniawan

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  1. Nyoman D. Kurniawan
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Correspondence to Nyoman D. Kurniawan .

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  1. BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain

    María Luisa García Martín

  2. Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, Madrid, Spain

    Pilar López Larrubia

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Kurniawan, N.D. (2018). MRI in the Study of Animal Models of Neurodegenerative Diseases. In: García Martín, M., López Larrubia, P. (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7531-0_21

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  • DOI: https://doi.org/10.1007/978-1-4939-7531-0_21

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