Preclinical MRI

Methods and Protocols

  • María Luisa García Martín
  • Pilar López Larrubia

Part of the Methods in Molecular Biology book series (MIMB, volume 1718)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. MRI Basics

    1. Front Matter
      Pages 1-1
    2. Gary V. Martinez
      Pages 3-19
    3. Daniel Calle, Teresa Navarro
      Pages 21-37
  3. Perfusion, Diffusion and Functional MRI

    1. Front Matter
      Pages 39-39
    2. Pilar López-Larrubia
      Pages 41-57
    3. Jennifer Moroz, Stefan A. Reinsberg
      Pages 71-87
    4. Irene Guadilla, Daniel Calle, Pilar López-Larrubia
      Pages 89-101
    5. Silvia Lope-Piedrafita
      Pages 103-116
    6. Laura Pérez-Cervera, José María Caramés, Luis Miguel Fernández-Mollá, Andrea Moreno, Begoña Fernández, Elena Pérez-Montoyo et al.
      Pages 117-134
    7. Rita Maria Rocha Oliveira, Irene Guadilla, Pilar López-Larrubia
      Pages 135-147
  4. In Vivo Spectroscopy

    1. Front Matter
      Pages 149-149
    2. M. Carmen Muñoz-Hernández, María Luisa García-Martín
      Pages 151-167
    3. Blanca Lizarbe, Antoine Cherix, Rolf Gruetter
      Pages 169-187
    4. Rui V. Simões, Emma Muñoz-Moreno, Raúl Tudela, Guadalupe Soria
      Pages 189-202
  5. Special MRI Techniques

    1. Front Matter
      Pages 203-203
    2. Ferdinand Schweser, Marilena Preda, Robert Zivadinov
      Pages 205-234
    3. Tuba Güden-Silber, Sebastian Temme, Christoph Jacoby, Ulrich Flögel
      Pages 235-257
    4. Bhanu Prakash KN, Jadegoud Yaligar, Sanjay K. Verma, Venkatesh Gopalan, S. Sendhil Velan
      Pages 259-268
    5. Min-Chi Ku, Till Huelnhagen, Thoralf Niendorf, Andreas Pohlmann
      Pages 269-284
    6. Jiangyang Zhang, Dan Wu, Daniel H. Turnbull
      Pages 285-296
    7. Heling Zhou, Nuria Arias-Ramos, Pilar López-Larrubia, Ralph P. Mason, Sebastián Cerdán, Jesús Pacheco-Torres
      Pages 297-313
    8. Maxime Gauberti, Antoine P. Fournier, Denis Vivien, Sara Martinez de Lizarrondo
      Pages 315-327
  6. MRI and MRS in Animal Models of Disease

    1. Front Matter
      Pages 329-329
    2. Menglin Cheng, Kristine Glunde
      Pages 331-345
    3. Pedro Ramos-Cabrer, Daniel Padro
      Pages 377-392
  7. Other Applications

    1. Front Matter
      Pages 393-393
    2. Min-Chi Ku, Sonia Waiczies, Thoralf Niendorf, Andreas Pohlmann
      Pages 395-408
    3. Carlos Caro, M. Carmen Muñoz-Hernández, Manuel Pernia Leal, María Luisa García-Martín
      Pages 409-419
  8. Anesthesia and Advanced Contrast Agents

    1. Front Matter
      Pages 421-421
    2. Jordi L. Tremoleda, Sven Macholl, Jane K. Sosabowski
      Pages 423-439
    3. Daniel Calle, Paloma Ballesteros, Sebastián Cerdán
      Pages 441-457
  9. Maxime Gauberti, Antoine P. Fournier, Denis Vivien, Sara Martinez de Lizarrondo
    Pages E1-E1
  10. Back Matter
    Pages 459-464

About this book


This volume discusses a variety of preclinical MRI methods and protocols to help technicians and researchers conduct studies in their respective fields. This book is organized into 7 parts: Part 1 covers the basics of MRI physics, relaxation, image contrast, and main acquisition sequences; Part 2 describes methodologies for diffusion, perfusion, and functional imaging; Part 3 looks at in vivo spectroscopy; Part 4 explores special MRI techniques that are less known in the field; Parts 5 and 6 discuss MRIs and MRSs in animal models of disease and the applications used to study them, and Part 7 looks at anesthesia and advanced contrast agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Comprehensive and thorough, Preclinical MRI: Methods and Protocols is a valuable resource for researchers interested in expanding their knowledge in this developing field.


pulse sequences Contrast agents Dynamic Susceptibility Contrast Arterial Spin Labelling (ALS) Dynamic Contrast Enhancement (DCE)

Editors and affiliations

  • María Luisa García Martín
    • 1
  • Pilar López Larrubia
    • 2
  1. 1.BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de AndalucíaUniversidad de MálagaSpain
  2. 2.Instituto de Investigaciones Biomédicas “Alberto Sols”CSIC/UAMSpain

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7530-3
  • Online ISBN 978-1-4939-7531-0
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site