In Vitro Models of Cutaneous Inflammation

  • Quentin Bernard
  • Benoît Jaulhac
  • Nathalie Boulanger
Part of the Methods in Molecular Biology book series (MIMB, volume 1690)


The skin plays an essential role in the transmission of Lyme borreliosis since it is the first interface between the Ixodes tick and the host during the inoculation of Borrelia burgdorferi sensu lato. A better understanding of the inflammatory reaction at this location is key to develop better strategies (e.g., vaccine and diagnosis) to fight this disease. In vitro cell culture of resident skin cells might constitute an approach to decipher the complex interplay between the tick, the pathogen, and the vertebrate host.

Key words

Skin Keratinocytes Fibroblasts Borrelia Tick saliva 


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Copyright information

© Springer Science+Business Media LLC 2018

Authors and Affiliations

  • Quentin Bernard
    • 1
  • Benoît Jaulhac
    • 2
    • 3
  • Nathalie Boulanger
    • 2
    • 3
  1. 1.Department of Veterinary Medicine, College Park and Virginia-Maryland College of Veterinary MedicineUniversity of MarylandCollege ParkUSA
  2. 2.EA7290: Virulence Bactérienne Précoce: Groupe Borréliose de LymeUniversité de StrasbourgStrasbourgFrance
  3. 3.Centre National de Reference BorreliaCentre Hospitalier UniversitaireStrasbourgFrance

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