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Post-analytical Issues in Hemostasis and Thrombosis Testing

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Hemostasis and Thrombosis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1646))

Abstract

Analytical concerns within hemostasis and thrombosis testing are continuously decreasing. This is essentially attributable to modern instrumentation, improvements in test performance and reliability, as well as the application of appropriate internal quality control and external quality assurance measures. Pre-analytical issues are also being dealt with in some newer instrumentation, which are able to detect hemolysis, icteria and lipemia, and, in some cases, other issues related to sample collection such as tube under-filling. Post-analytical issues are generally related to appropriate reporting and interpretation of test results, and these are the focus of the current overview, which provides a brief description of these events, as well as guidance for their prevention or minimization. In particular, we propose several strategies for improved post-analytical reporting of hemostasis assays and advise that this may provide the final opportunity to prevent serious clinical errors in diagnosis.

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Abbreviations

APCR:

Activated protein C resistance

aCL:

Anticardiolipin antibody (assay)

aPL:

Antiphospholipid antibody

APS:

Antiphospholipid (antibody) syndrome

APTT:

Activated partial thromboplastin time

AT:

Antithrombin

dRVVT:

Dilute Russell viper venom time

FVL:

Factor V Leiden

KCT:

Kaolin clotting time

LA:

Lupus anticoagulant

PC:

Protein C

PS:

Protein S

VKA:

Vitamin K antagonist

VWF:

von Willebrand factor

VWD:

von Willebrand disease

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Author information

Authors and Affiliations

  1. Haematology Department, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, NSW Health Pathology, Westmead, NSW, 2145, Australia

    Emmanuel J. Favaloro

  2. Section of Clinical Biochemistry, University of Verona, Verona, Italy

    Giuseppe Lippi

Authors
  1. Emmanuel J. Favaloro
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  2. Giuseppe Lippi
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Corresponding author

Correspondence to Emmanuel J. Favaloro .

Editor information

Editors and Affiliations

  1. Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology, Westmead Hospital, Westmead, New South Wales, Australia

    Emmanuel J. Favaloro

  2. Section of Clinical Biochemistry, University of Verona, Verona, Italy

    Giuseppe Lippi

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Favaloro, E.J., Lippi, G. (2017). Post-analytical Issues in Hemostasis and Thrombosis Testing. In: Favaloro, E., Lippi, G. (eds) Hemostasis and Thrombosis. Methods in Molecular Biology, vol 1646. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7196-1_40

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  • DOI: https://doi.org/10.1007/978-1-4939-7196-1_40

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7194-7

  • Online ISBN: 978-1-4939-7196-1

  • eBook Packages: Springer Protocols

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