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Link of Zygotic Genome Activation and Cell Cycle Control

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Zygotic Genome Activation

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1605))

Abstract

The activation of the zygotic genome and onset of transcription in blastula embryos is linked to changes in cell behavior and remodeling of the cell cycle and constitutes a transition from exclusive maternal to zygotic control of development. This step in development is referred to as mid-blastula transition and has served as a paradigm for the link between developmental program and cell behavior and morphology. Here, we discuss the mechanism and functional relationships between the zygotic genome activation and cell cycle control during mid-blastula transition with a focus on Drosophila embryos.

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Acknowledgment

BL was supported by China Scholarship Council. The work in JG’s laboratory was in part supported by the German Research Council (Deutsche Forschungsgemeinschaft (DFG) GR1945/3-1, SFB937/TP10).

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  1. Institute for Developmental Biochemistry, Medical School, University of Göttingen, Justus-von-Liebig-Weg11, Göttingen 37077, Germany

    Boyang Liu & Jörg Grosshans

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  1. Boyang Liu
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  2. Jörg Grosshans
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Correspondence to Jörg Grosshans .

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  1. Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, Virginia, USA

    Kiho Lee

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Liu, B., Grosshans, J. (2017). Link of Zygotic Genome Activation and Cell Cycle Control. In: Lee, K. (eds) Zygotic Genome Activation. Methods in Molecular Biology, vol 1605. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6988-3_2

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  • DOI: https://doi.org/10.1007/978-1-4939-6988-3_2

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