Antibiotics pp 49-61 | Cite as

Production of Antimicrobial Compounds by Fermentation

  • Henrik Harms
  • Gabriele M. König
  • Till F. Schäberle
Part of the Methods in Molecular Biology book series (MIMB, volume 1520)


The production of biologically active metabolites, e.g., antimicrobial compounds, is an essential step in the discovery and development process of medicinal drugs based on natural products. To get a hand on the compound of interest it first has to be biosynthesized by the corresponding producer, mostly a microorganism. In this chapter, a general workflow, which can easily be adapted to the lab, is described. Both fermentation on solid and in liquid medium is explained, and examples of hand on procedures are given.

Key words

Microorganisms Purification Growth media 



This work was supported by the German Federal Ministry of Education and Research (BMBF) through the German Centre for Infection Research (DZIF) initiative.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Henrik Harms
    • 1
  • Gabriele M. König
    • 1
  • Till F. Schäberle
    • 1
  1. 1.Department of Pharmaceutical BiologyUniversity of BonnBonnGermany

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