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Inferring Functional Relationships from Conservation of Gene Order

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Bioinformatics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1526))

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Abstract

Predicting functional associations using the Gene Neighbor Method depends on the simple idea that if genes are conserved next to each other in evolutionarily distant prokaryotes they might belong to a polycistronic transcription unit. The procedure presented in this chapter starts with the organization of the genes within genomes into pairs of adjacent genes. Then, the pairs of adjacent genes in a genome of interest are mapped to their corresponding orthologs in other, informative, genomes. The final step is to verify if the mapped orthologs are also pairs of adjacent genes in the informative genomes.

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Acknowledgments

This work was supported by a Discovery Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC).

Author information

Authors and Affiliations

  1. Department of Biology, Wilfrid Laurier University, 75 University Ave W, Waterloo, ON, Canada, N2L 3C5

    Gabriel Moreno-Hagelsieb

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  1. Gabriel Moreno-Hagelsieb
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Corresponding author

Correspondence to Gabriel Moreno-Hagelsieb .

Editor information

Editors and Affiliations

  1. Monash University, Melbourne, Victoria, Australia

    Jonathan M. Keith

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Moreno-Hagelsieb, G. (2017). Inferring Functional Relationships from Conservation of Gene Order. In: Keith, J. (eds) Bioinformatics. Methods in Molecular Biology, vol 1526. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6613-4_3

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  • DOI: https://doi.org/10.1007/978-1-4939-6613-4_3

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6611-0

  • Online ISBN: 978-1-4939-6613-4

  • eBook Packages: Springer Protocols

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