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Molecular Network Dynamics of Cell Cycle Control: Periodicity of Start and Finish

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Cell Cycle Synchronization

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1524))

Abstract

The cell division cycle is controlled by a complex regulatory network which ensures that the phases of the cell cycle are executed in the right order. This regulatory network receives signals from the environment, monitors the state of the DNA, and decides timings of cell cycle events. The underlying transcriptional and post-translational regulatory interactions lead to complex dynamical responses, such as the oscillations in the levels of cell cycle proteins driven by intertwined biochemical reactions. A cell moves between different phases of its cycle similar to a dynamical system switching between its steady states. The complex molecular network driving these phases has been investigated in previous computational systems biology studies. Here, we review the critical physiological and molecular transitions that occur in the cell cycle and discuss the role of mathematical modeling in elucidating these transitions and understand cell cycle synchronization.

The original version of this chapter was revised. The erratum to this chapter is available at: DOI 10.1007/978-1-4939-6603-5_22

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Disclaimer

This article was prepared while Alida Palmisano and Cihan Oguz were employed at Virginia Tech. The opinions expressed in this article are the authors’ own and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government.

Author information

Authors and Affiliations

  1. Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA

    Alida Palmisano & Cihan Oguz

  2. Department of Computer Science, Virginia Tech, Blacksburg, VA, USA

    Alida Palmisano

  3. Hungarian Academy of Sciences, Research Centre for Natural Sciences, Institute of Enzymology, Budapest, Hungary

    Judit Zámborszky

  4. Randall Division of Cell and Molecular Biophysics, Institute for Mathematical and Molecular Biomedicine, King’s College London, London, UK

    Attila Csikász-Nagy

  5. Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary

    Attila Csikász-Nagy

Authors
  1. Alida Palmisano
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  2. Judit Zámborszky
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  3. Cihan Oguz
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  4. Attila Csikász-Nagy
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Corresponding author

Correspondence to Alida Palmisano .

Editor information

Editors and Affiliations

  1. Department of Biotechnology and Microbiology, University of Debrecen, Debrecen, Hungary

    Gaspar Banfalvi

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Palmisano, A., Zámborszky, J., Oguz, C., Csikász-Nagy, A. (2017). Molecular Network Dynamics of Cell Cycle Control: Periodicity of Start and Finish . In: Banfalvi, G. (eds) Cell Cycle Synchronization. Methods in Molecular Biology, vol 1524. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6603-5_21

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  • DOI: https://doi.org/10.1007/978-1-4939-6603-5_21

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6602-8

  • Online ISBN: 978-1-4939-6603-5

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