Abstract
Inflammatory bowel diseases (IBDs) are complex multifactorial disease thought to result from inappropriate immune responses to the gut microbiota, in genetically susceptible individuals, under the influence of environmental factors. Among the different animal models developed to help in understanding IBDs pathophysiological mechanisms as well as to achieve pharmacological preclinical studies, the dextran sulfate sodium (DSS)-induced colitis model is the most widely used because of its simplicity, cost-effectiveness, and similarity with human IBDs. This section provides with a detailed protocol that we validated in our laboratory to perform DSS-induced acute colitis in the Sprague-Dawley (SPD) rat.
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Martin, J.C., Bériou, G., Josien, R. (2016). Dextran Sulfate Sodium (DSS)-Induced Acute Colitis in the Rat. In: Cuturi, M., Anegon, I. (eds) Suppression and Regulation of Immune Responses. Methods in Molecular Biology, vol 1371. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3139-2_12
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DOI: https://doi.org/10.1007/978-1-4939-3139-2_12
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-3138-5
Online ISBN: 978-1-4939-3139-2
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