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Autoshaping Memory Formation and Retention Loss: Are Serotonin and Other Neurotransmitter Transporters Involved?

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Serotonin Receptor Technologies

Part of the book series: Neuromethods ((NM,volume 95))

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Abstract

Several neurotransmitter systems play a pivotal role in the process of memory formation. The role of these systems in the process of retention loss or “forgetting,” especially that of reuptake transporters for γ-aminobutyric acid (GAT1), glutamate (EAAT1), dopamine (DAT), and serotonin (SERT), is poorly understood. In this paper, Western blot analysis was used to evaluate expression of GAT1, EAAT1, DAT, and SERT in rats under conditions allowing to study memory, amnesia, forgetting processes. Trained and untrained rats were pharmacologically treated with substances modifying serotonergic neurotransmission. Data show that, on one hand, forgetting can be considered as a behavioral process that is difficult to modify but, on the other hand, to prevent forgetting processes might be achieved by interfering with the expression pattern or functional activity of different specific neurotransmitter transporters.

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Acknowledgments

This work was supported in part by CONACYT grant 80060. R. T. was supported by CONACYT scholarship (No.219677).

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Authors and Affiliations

  1. Depto. de Farmacobiología, CINVESTAV-IPN, Tenorios 235, Granjas Coapa, Mexico City, 14330, Mexico

    Alfredo Meneses & Ruth Tellez

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  1. Alfredo Meneses
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  2. Ruth Tellez
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Correspondence to Alfredo Meneses .

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Editors and Affiliations

  1. Universität zu Köln, Köln, Germany

    Wolfgang Blenau

  2. Forschungszentrum Jülich, Jülich, Germany

    Arnd Baumann

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Meneses, A., Tellez, R. (2015). Autoshaping Memory Formation and Retention Loss: Are Serotonin and Other Neurotransmitter Transporters Involved?. In: Blenau, W., Baumann, A. (eds) Serotonin Receptor Technologies. Neuromethods, vol 95. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2187-4_7

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  • DOI: https://doi.org/10.1007/978-1-4939-2187-4_7

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2186-7

  • Online ISBN: 978-1-4939-2187-4

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