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Epigenetics of Cognition and Neurodegenerative Disorders

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The Maze Book

Part of the book series: Neuromethods ((NM,volume 94))

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Abstract

Epigenetics is defined as alterations in RNA transcript expression, or the phenotype of the cell, that are caused by mechanisms other than changes in the associated DNA sequence. This chapter focuses on the general process of gene transcription. It also discusses how epigenetics intervenes in this process, the heritability of cognitive performance, as well as relations between cognition and DNA methylation, histone and chromatin changes, and micro RNAs. In addition, also summarized here is the current state of knowledge surrounding the role of epigenetics in the most common neurodegenerative diseases. Highlighted are the complex regulatory networks at play in the healthy and diseased nervous system, and the tenet that the research findings are promising and suggest new therapeutic avenues.

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Authors and Affiliations

  1. Banner Sun Health Research Institute, Sun City, AZ, 85351, USA

    Paul Coleman

  2. The Arizona Alzheimer’s Consortium, 4745 N 7th St # 105, Phoenix, AZ, 85014, USA

    Paul Coleman, Matthew Huentelman Ph.D. & Travis Dunckley

  3. Neurogenomics Division, The Translational Genomics Research Institute (TGen), Phoenix, AZ, 85004, USA

    Matthew Huentelman Ph.D. & Travis Dunckley

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  1. Paul Coleman
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  2. Matthew Huentelman Ph.D.
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Correspondence to Matthew Huentelman Ph.D. .

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Editors and Affiliations

  1. Arizona State University, Tempe, Arizona, USA

    Heather A. Bimonte-Nelson

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Coleman, P., Huentelman, M., Dunckley, T. (2015). Epigenetics of Cognition and Neurodegenerative Disorders. In: Bimonte-Nelson, H. (eds) The Maze Book. Neuromethods, vol 94. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2159-1_10

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  • DOI: https://doi.org/10.1007/978-1-4939-2159-1_10

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