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Analysis of Biomolecular Dynamics by FRAP and Computer Simulation

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Advanced Fluorescence Microscopy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1251))

Abstract

We present a Monte Carlo simulation environment for modelling complex biological molecular interaction networks and for the design, validation, and quantitative analysis of FRAP assays to study these. The program is straightforward in its implementation and can be instructed through an intuitive script language. The simulation tool fits very well in a systems biology research setting that aims to maintain an interactive cycle of experiment-driven modelling and model-driven experimentation: the model and the experiment are in the same simulation. The full program can be obtained by request to the authors.

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Author information

Authors and Affiliations

  1. Department of Pathology, Josephine Nefkens Institute, Erasmus Optical Imaging Centre, Erasmus MC, Postbus 2040, Rotterdam, 3000 CA, The Netherlands

    Bart Geverts, Martin E. van Royen & Adriaan B. Houtsmuller

Authors
  1. Bart Geverts
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  2. Martin E. van Royen
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  3. Adriaan B. Houtsmuller
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Corresponding author

Correspondence to Adriaan B. Houtsmuller .

Editor information

Editors and Affiliations

  1. Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

    Peter J. Verveer

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Geverts, B., van Royen, M.E., Houtsmuller, A.B. (2015). Analysis of Biomolecular Dynamics by FRAP and Computer Simulation. In: Verveer, P. (eds) Advanced Fluorescence Microscopy. Methods in Molecular Biology, vol 1251. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2080-8_7

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  • DOI: https://doi.org/10.1007/978-1-4939-2080-8_7

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2079-2

  • Online ISBN: 978-1-4939-2080-8

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