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Exploring Mesenchymal Stem Cell-Derived Extracellular Vesicles in Acute Kidney Injury

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Animal Models for Stem Cell Therapy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1213))

Abstract

Several experimental animal models have been set up to study the characteristics of acute kidney injury (AKI) and to develop possible new treatments for clinical applications. Herein, we review the experimental procedures used to induce AKI to test the therapeutic potential of extracellular vesicles (EV) produced by stem cells. In particular, we focused on AKI models induced by rhabdomyolysis, by cisplatin treatment, and by renal ischemia–reperfusion injury.

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Author information

Authors and Affiliations

  1. Department of Molecular Biotechnology and Healthy Science, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, Italy

    Stefania Bruno

  2. Department of Medical Sciences; Department of Molecular Biotechnology and Healthy Science, University of Torino, Torino, Italy

    Giovanni Camussi

Authors
  1. Stefania Bruno
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  2. Giovanni Camussi
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Corresponding author

Correspondence to Stefania Bruno .

Editor information

Editors and Affiliations

  1. Department of Surgery, Unviersity of Leipzig, Germany

    Bruno Christ

  2. Department of Surgery, University of Leipzig, Germany

    Jana Oerlecke

  3. Department of Surgery, University of Leipzig, Germany

    Peggy Stock

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© 2014 Springer Science+Business Media New York

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Bruno, S., Camussi, G. (2014). Exploring Mesenchymal Stem Cell-Derived Extracellular Vesicles in Acute Kidney Injury. In: Christ, B., Oerlecke, J., Stock, P. (eds) Animal Models for Stem Cell Therapy. Methods in Molecular Biology, vol 1213. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1453-1_12

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  • DOI: https://doi.org/10.1007/978-1-4939-1453-1_12

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1452-4

  • Online ISBN: 978-1-4939-1453-1

  • eBook Packages: Springer Protocols

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