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Target Selection for Structural Genomics of Infectious Diseases

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Structural Genomics and Drug Discovery

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1140))

Abstract

This chapter describes the protocols used to identify, filter, and annotate potential protein targets from an organism associated with infectious diseases. Protocols often combine computational approaches for mining information in public databases or for checking whether the protein has already been targeted for structure determination, with manual strategies that examine the literature for information on the biological role of the protein or the experimental strategies that explore the effects of knocking out the protein. Publicly available computational tools have been cited as much as possible. Where these do not exist, the concepts underlying in-house tools developed for the Center for Structural Genomics of Infectious Diseases have been described.

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Acknowledgments

Drs. Corin Yeats and Benoit Dessailly are supported with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract Nos. HHSN272200700058C and HHSN272201200026C.

Author information

Authors and Affiliations

  1. Dept. of Structural and Molecular Biology, University College London, Gower Street, WC1E 6BT, London, UK

    Corin Yeats, Benoit H. Dessailly & Christine A. Orengo

  2. Center for Structural Genomics of Infectious Diseases, University College London, Gower Street, WC1E 6BT, London, UK

    Corin Yeats, Benoit H. Dessailly & Christine A. Orengo

  3. Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA

    Elizabeth M. Glass

  4. Department of Pathology and Immunology, Department of Biochemistry and Molecular Biophysics, Washington University, St. Louis, MO, 63110, USA

    Daved H. Fremont

Authors
  1. Corin Yeats
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  2. Benoit H. Dessailly
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  3. Elizabeth M. Glass
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  4. Daved H. Fremont
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  5. Christine A. Orengo
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Corresponding author

Correspondence to Christine A. Orengo .

Editor information

Editors and Affiliations

  1. Center for Structural Genomics of Infectious Diseases Midwest Center for Structural Genomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Wayne F. Anderson

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Yeats, C., Dessailly, B.H., Glass, E.M., Fremont, D.H., Orengo, C.A. (2014). Target Selection for Structural Genomics of Infectious Diseases. In: Anderson, W.F. (eds) Structural Genomics and Drug Discovery. Methods in Molecular Biology, vol 1140. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-0354-2_3

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  • DOI: https://doi.org/10.1007/978-1-4939-0354-2_3

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-0353-5

  • Online ISBN: 978-1-4939-0354-2

  • eBook Packages: Springer Protocols

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