Structural Genomics and Drug Discovery

Methods and Protocols

  • Wayne F. Anderson

Part of the Methods in Molecular Biology book series (MIMB, volume 1140)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Matthew D. Zimmerman, Marek Grabowski, Marcin J. Domagalski, Elizabeth M. MacLean, Maksymilian Chruszcz, Wladek Minor
    Pages 1-25
  3. Khan Tanjid Osman, Aled Edwards
    Pages 27-34
  4. Corin Yeats, Benoit H. Dessailly, Elizabeth M. Glass, Daved H. Fremont, Christine A. Orengo
    Pages 35-51
  5. Isabelle Q. H. Phan, Robin Stacy, Peter J. Myler
    Pages 53-59
  6. Keehwan Kwon, Scott N. Peterson
    Pages 61-74
  7. Keehwan Kwon, Scott N. Peterson
    Pages 75-88
  8. Magdalena Makowska-Grzyska, Youngchang Kim, Natalia Maltseva, Hui Li, Min Zhou, Grazyna Joachimiak et al.
    Pages 89-105
  9. Christopher A. Nelson, William H. McCoy, Daved H. Fremont
    Pages 107-116
  10. Emily T. Beebe, Shin-ichi Makino, John L. Markley, Brian G. Fox
    Pages 117-135
  11. Ludmilla Shuvalova
    Pages 137-143
  12. Christopher A. Nelson, Chung A. Lee, Daved H. Fremont
    Pages 145-157
  13. Tatiana Skarina, Xiaohui Xu, Elena Evdokimova, Alexei Savchenko
    Pages 159-168
  14. Adelinda A. Yee, Anthony Semesi, Maite Garcia, Cheryl H. Arrowsmith
    Pages 169-178
  15. Yufeng Tong, Aiping Dong, Xiaohui Xu, Amy Wernimont
    Pages 179-188
  16. Kemin Tan, Youngchang Kim, Catherine Hatzos-Skintges, Changsoo Chang, Marianne Cuff, Gekleng Chhor et al.
    Pages 189-200
  17. Lukasz Goldschmidt, David Eisenberg, Zygmunt S. Derewenda
    Pages 201-209
  18. Kanagalaghatta Rajashankar, Zbigniew Dauter
    Pages 211-237
  19. George Minasov, Wayne F. Anderson
    Pages 239-249
  20. T. Andrew Binkowski, Wei Jiang, Benoit Roux, Wayne F. Anderson, Andrzej Joachimiak
    Pages 251-261

About this book

Introduction

Structural Genomics and Drug Discovery: Methods and Protocols focuses  on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery.​Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and practical, Structural Genomics and Drug Discovery: Methods and Protocols seeks to aid scientists in the further study into structural genomics approach as an efficient initial step toward drug discovery and the methods described will be useful to anyone interested in moving in this direction.

Keywords

Structural Genomics bio-informatics cloning crystallization screening data management drug discovery expression and solubility testing genome sequencing macromolecular structure determination protein production purification screening for suitability for NMR structure determination structure aided drug discovery structure determination methods

Editors and affiliations

  • Wayne F. Anderson
    • 1
  1. 1.Northwestern University Feinberg School of MedicineChicagoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-0354-2
  • Copyright Information Springer Science+Business Media, New York 2014
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-0353-5
  • Online ISBN 978-1-4939-0354-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book