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Measurement of Murine Neuromuscular Function Using the In Situ Preparation

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Neurobiology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2746))

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Abstract

The presence and progression of a neuromuscular pathology can impact on the contractile force production of a muscle. Hence, measurements of force production can be an important tool for the evaluation of disease progression. In this chapter, we describe how to perform in situ function testing on the tibialis anterior muscle using a murine model. Performing neuromuscular in situ function testing allows force measurements to be recorded in a physiologically relevant environment.

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Authors and Affiliations

  1. Department of Microbiology, Anatomy, Physiology & Pharmacology, School of Agriculture, Biomedicine & Environment, La Trobe University, Melbourne, VIC, Australia

    S. T. C. Kucewicz & C. van der Poel

  2. Aurora Scientific, Aurora, ON, Canada

    M. Borkowski & J. E. Church

Authors
  1. S. T. C. Kucewicz
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  2. M. Borkowski
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  3. J. E. Church
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  4. C. van der Poel
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Corresponding author

Correspondence to C. van der Poel .

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Editors and Affiliations

  1. Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, VIC, Australia

    Sebastian Dworkin

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© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Kucewicz, S.T.C., Borkowski, M., Church, J.E., van der Poel, C. (2024). Measurement of Murine Neuromuscular Function Using the In Situ Preparation. In: Dworkin, S. (eds) Neurobiology. Methods in Molecular Biology, vol 2746. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3585-8_12

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  • DOI: https://doi.org/10.1007/978-1-0716-3585-8_12

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3584-1

  • Online ISBN: 978-1-0716-3585-8

  • eBook Packages: Springer Protocols

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