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Animal Models of PTSD: The Role of Fear Conditioning

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Translational Methods for PTSD Research

Part of the book series: Neuromethods ((NM,volume 198))

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Abstract

Adverse situations that challenge an individual’s physical or psychological integrity are frequent throughout the lifespan. However, some situations go beyond the adaptive capacity and are considered traumatic, leading, in some individuals, to the development of post-traumatic stress disorder (PTSD), a condition characterized by persistent recollection of the trauma, avoidance of trauma-related cues, increased arousal, and fear generalization and sensitization. Some of these symptoms indicate that fear conditioning (cue or context-based) plays a major role in this disorder. Because individual variability is a major feature of PTSD, it is crucial to understand the psychological and biological factors that confer vulnerability and resilience to the development of this disorder. Animal models based on fear conditioning, which incorporates individual variability and sex differences, could, therefore, increase the translational value and validity of these models for testing of potential pharmacological and non-pharmacological treatments. In the present chapter, we will present the behavioral and neurobiological outcomes of animal models of PTSD based on paradigms of fear conditioning and the putative systems that may be involved with vulnerability and resilience. We will close the chapter by presenting the gaps in the literature and propose future directions on how to fill them in.

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Authors and Affiliations

  1. Department of Psychobiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

    Mariella B. L. Careaga, Carlos Eduardo Neves Girardi & Deborah Suchecki

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  1. Mariella B. L. Careaga
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  2. Carlos Eduardo Neves Girardi
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  3. Deborah Suchecki
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Correspondence to Deborah Suchecki .

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  1. Psychiatric Institute, University of Chicago, Chicago, IL, USA

    Graziano Pinna

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Careaga, M.B.L., Girardi, C.E.N., Suchecki, D. (2023). Animal Models of PTSD: The Role of Fear Conditioning. In: Pinna, G. (eds) Translational Methods for PTSD Research. Neuromethods, vol 198. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3218-5_11

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  • DOI: https://doi.org/10.1007/978-1-0716-3218-5_11

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