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Preparation of Dried Amniotic Membrane for Corneal Repair

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Corneal Regeneration

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2145))

Abstract

Amniotic membrane transplantation is an established therapeutic and biological adjunct for several clinical situations, including treatment of diabetic foot ulcers and ocular surface disease. However, poorly standardized and validated clinical preparation and storage procedures can render the final product highly variable and an unpredictable biomaterial. We have therefore developed a novel, standardized method for processing and dry-preserving amniotic membrane, minimizing biochemical, compositional, and structure damage to produce a potentially superior membrane suitable for clinical use. The intellectual property associated with this methodology was patented by the University of Nottingham and licensed to NuVision® Biotherapies which formed the basis of the Tereo® manufacturing process which is used to manufacture Omnigen®.

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Authors and Affiliations

  1. Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK

    Andrew Hopkinson, Emily R. Britchford & Laura E. Sidney

  2. NuVision Biotherapies Ltd, MediCity, Nottingham, UK

    Andrew Hopkinson & Emily R. Britchford

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  1. Andrew Hopkinson
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  2. Emily R. Britchford
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  3. Laura E. Sidney
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Correspondence to Andrew Hopkinson .

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Editors and Affiliations

  1. Trinity Centre for Biomedical Engineering, Trinity College Dublin, Dublin, Ireland

    Mark Ahearne

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Hopkinson, A., Britchford, E.R., Sidney, L.E. (2020). Preparation of Dried Amniotic Membrane for Corneal Repair. In: Ahearne, M. (eds) Corneal Regeneration. Methods in Molecular Biology, vol 2145. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0599-8_10

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  • DOI: https://doi.org/10.1007/978-1-0716-0599-8_10

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  • Publisher Name: Humana, New York, NY

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