Abstract
Chemical modifications of proteins may be performed simply and rapidly, and can readily provide preliminary data regarding the role of particular amino acids in a given protein. Even in the era of molecular biology, when site-directed mutagenesis has become so popular, selective chemical modifications are often useful. Many reviews and books cover these aspects of protein chemistry; only a few are cited here (1–4). In particular, the book by Means and Feeney (1), although more than 20 years old, is an excellent introduction and a practical guide to this field.
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References
Means, G. E. and Feeney, R. E. (1971) Chemical Modifications of Proteins. Holden-Day, San Francisco, CA.
Hirs, C. H. N. and Timasheff, S. N. (eds.) (1972) Enzyme Structure B. Methods Enzymology 25.
Lundblad, R. L. and Noyes, C. M. (1984) Chemical Reagents for Protein Modifications, vols. 1 and 2. CRC, Boca Raton, FL.
Feeney, R. E. (1987) Chemical modification of proteins: comments and perspectives. Int. J. Pept. Protein Res. 27, 145–161.
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© 1996 Humana Press Inc., Totowa, NJ
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Tawfik, D.S. (1996). Side-Chain Selective Chemical Modifications of Proteins. In: Walker, J.M. (eds) The Protein Protocols Handbook. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-259-9_55
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DOI: https://doi.org/10.1007/978-1-60327-259-9_55
Publisher Name: Humana Press
Print ISBN: 978-0-89603-338-2
Online ISBN: 978-1-60327-259-9
eBook Packages: Springer Book Archive