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Pharmaco-Based fMRI and Neurophysiology in Non-Human Primates

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In Vivo Neuropharmacology and Neurophysiology

Part of the book series: Neuromethods ((NM,volume 121))

Abstract

Brain activity is continuously changing, among others reflecting the effects of neuromodulation on multiple spatial and temporal scales. By altering the input–output relationship of neural circuits, neuromodulators can also affect their energy expenditure, with concomitant effects on the hemodynamic responses. Yet, it is still unclear how to study and interpret the effects of different neuromodulators, for instance, how to differentiate their effects from underlying behavior- or stimulus-driven activity. Gaining insights into neuromodulatory processes is largely hampered by the lack of approaches providing information concurrently at different spatio-temporal scales. Here, we provide an overview of the multimodal approach consisting of functional magnetic resonance imaging (fMRI), pharmacology and neurophysiology, which we developed to elucidate causal relationships between neuromodulation and neurovascular coupling in visual cortex of anesthetized macaques.

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Acknowledgements

Thanks to Dr. Andre Marreiros for critical comments on the manuscript and discussion. This work was supported by the Max Planck Society.

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Authors and Affiliations

  1. Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076, Tübingen, Germany

    Daniel Zaldivar, Nikos K. Logothetis, Alexander Rauch & Jozien Goense

  2. IMPRS for Cognitive and Systems Neuroscience, University of Tübingen, Österbergstrasse 3, 72074, Tübingen, Germany

    Daniel Zaldivar

  3. Division of Imaging Science and Biomedical Engineering, University of Manchester, Manchester, M13 9PT, UK

    Nikos K. Logothetis

  4. University Hospital of Psychiatry, University of Bern, 3000, Bern, Switzerland

    Alexander Rauch

  5. Institute of Neuroscience and Psychology, University of Glasgow, 58 Hillhead Street, Glasgow, G12 8QB, UK

    Jozien Goense

Authors
  1. Daniel Zaldivar
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  2. Nikos K. Logothetis
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  3. Alexander Rauch
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  4. Jozien Goense
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Correspondence to Daniel Zaldivar or Jozien Goense .

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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Austria

    Athineos Philippu

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Zaldivar, D., Logothetis, N.K., Rauch, A., Goense, J. (2017). Pharmaco-Based fMRI and Neurophysiology in Non-Human Primates. In: Philippu, A. (eds) In Vivo Neuropharmacology and Neurophysiology. Neuromethods, vol 121. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6490-1_3

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  • DOI: https://doi.org/10.1007/978-1-4939-6490-1_3

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