Volume 26, Issue 11

Search all Medicinal Chemistry Research articles

November 2017

35 articles in this issue

Towards the design of 3-aminopyrazole pharmacophore of pyrazolopyridine derivatives as novel antioxidants
Apilak Worachartcheewan
Chanin Nantasenamat
Virapong Prachayasittikul
Original Research 30 June 2017 Pages: 2699 - 2706
Discovery two potent and new inhibitors of 15-lipoxygenase: (E)-3-((3,4-dihydroxybenzylidene) amino)-7-hydroxy-2H-chromen-2-one and (E)-O-(4-(((7-hydroxy-2-oxo-2H-chromen-3-yl) imino)methine) phenyl)dimethylcarbamothioate
Carolina Nuñez
Nicole Morales
Angelica Fierro
Original Research 07 July 2017 Pages: 2707 - 2717
Design, synthesis, and docking studies of new 2-benzoxazolinone derivatives as anti-HIV-1 agents
Mahdieh Safakish
Zahra Hajimahdi
Afshin Zarghi
Original Research 03 July 2017 Pages: 2718 - 2726
Involvement of reactive oxygen species in the oleoylethanolamide effects and its pyrazonilic analogue in melanoma cells
Priscila Antiqueira-Santos
Daiane S. dos Santos
Ana Paula S. Votto
Original Research 01 July 2017 Pages: 2727 - 2736
Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitors
Elmira F. Khusnutdinova
Irina E. Smirnova
Do Quoc Viet
Original Research 07 July 2017 Pages: 2737 - 2742
Phytochemical characterization and biological activity of secondary metabolites from three Limonium species
Anastassiya V. Gadetskaya
Shaymaa M. Mohamed
Samir A. Ross
Original Research 12 July 2017 Pages: 2743 - 2750
RETRACTED ARTICLE: Rhodozepinone, a new antitrypanosomal azepino-diindole alkaloid from the marine sponge-derived bacterium Rhodococcus sp. UA13
Yasmin Elsayed
John Refaat
Mostafa A. Fouad
Original Research 15 July 2017 Pages: 2751 - 2760
Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities
Xiang Dong Su
Wei Li
Young Ho Kim
Original Research 31 August 2017 Pages: 2761 - 2767
Docking-based comparative intermolecular contacts analysis and in silico screening reveal new potent acetylcholinesterase inhibitors
Maha Habash
Sawsan Abuhamdah
Mutasem O. Taha
Original Research 11 July 2017 Pages: 2768 - 2784
Design, synthesis, estrogenic and antiestrogenic activities of some triarylpyrazole derivatives
Mahmoud A. Ragab
Heba A. Abd El Razik
Nargues S. Habib
Original Research 19 July 2017 Pages: 2785 - 2808
Choline kinase inhibition and docking studies of a series of 6-(benzylthio)-9H-purin-9-yl-pyridinium derivatives
Belén Rubio-Ruiz
Pablo Ríos-Marco
Antonio Entrena
Original Research 11 July 2017 Pages: 2809 - 2815
Liuweibuqi capsules suppress inflammation by affecting T cell polarization and survival in chronic obstructive pulmonary disease
Chengyang Wang
Huanzhang Ding
Lei Gan
Original Research 13 July 2017 Pages: 2816 - 2823
Structure-based rational design of peptide inhibitors to disrupt the recognition and interaction between hepatitis B virus large envelope protein and human hepatocyte receptor γ2-adaptin
Kuifeng Wang
Chunying Yang
Jiansheng Zhu
Original Research 19 July 2017 Pages: 2824 - 2831
Design, synthesis, and biological evaluation of 4-H pyran derivatives as antimicrobial and anticancer agents
Thatikonda Narendar Reddy
Mettu Ravinder
Vaidya Jayathirtha Rao
Original Research 17 July 2017 Pages: 2832 - 2844
Bioguided study of the in vitro parasitocidal effect on adult Hymenolepis nana of the Psidium sartorianum (O. Berg Nied.) fruit methanol extract
Julio Montes-Avila
Sylvia Páz Díaz-Camacho
Francisco Delgado-Vargas
Original Research 19 July 2017 Pages: 2845 - 2852
Antiproliferative effect of apocynin in cervical epithelial cells infected by HPV 16 involves change of ROS production and cell cycle
Natália Alves Lima
Natália de Carvalho Scharf Santana
Sueli de Oliveira Silva
Original Research 19 July 2017 Pages: 2853 - 2860
Synthesis, cytotoxicity and pro-apoptosis activity of isoquinoline quinones
Hua Ni
Chao Xia
Yu Zhao
Original Research 19 July 2017 Pages: 2861 - 2869
PTP1B inhibitory and cytotoxic activities of triterpenoids from the aerial parts of Agrimonia pilosa
Bing Tian Zhao
Duc Hung Nguyen
Mi Hee Woo
Original Research 20 July 2017 Pages: 2870 - 2878
Design, synthesis and biological evaluation of urea-based benzamides derivatives as HDAC inhibitors
Yong Zhu
Xin Chen
Weifang Tang
Original Research 26 July 2017 Pages: 2879 - 2888
Synthesis, antimycobacterial screening and molecular docking studies of 4-aryl-4′-methyl-2′-aryl-2,5′-bisthiazole derivatives
Yogita K. Abhale
Abhijit D. Shinde
Pravin C. Mhaske
Original Research 21 July 2017 Pages: 2889 - 2899
Isolation of three new metabolites and intervention of diazomethane led to separation of compound 1 & 2 from an endophytic fungus, Cryptosporiopsis sp. depicting cytotoxic activity
Sunil Kumar
Yedukondalu Nalli
Asif Ali
Original Research 28 July 2017 Pages: 2900 - 2908
Synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine-3-carboxamide as antimicrobial agents
Ashraf S. Hassan
Doaa M. Masoud
Ahmed A. Askar
Original Research 21 July 2017 Pages: 2909 - 2919
The effects of flavonoid compound from Agrimonia pilosa Ledeb on promotting 3T3-L1 preadipocytes differentiation by activating PPARγ partially
Liancai Zhu
Jun Tan
Bochu Wang
Original Research 05 August 2017 Pages: 2920 - 2928
Imatinib derivatives as inhibitors of K562 cells in chronic myeloid leukemia
Liviane D. Azevedo
Mônica M. Bastos
Nubia Boechat
Original Research 04 September 2017 Pages: 2929 - 2941
Antiacetylcholinesterase activity and docking studies with chlorogenic acid, cynarin and arzanol from Helichrysum stoechas (Lamiaceae)
Letícia Silva
Ana Margarida Rodrigues
Maria Luísa Marques Serralheiro
Original Research 29 July 2017 Pages: 2942 - 2950
Design, synthesis and CoMFA studies of OEA derivatives as FAAH inhibitors
Daxiong Han
Biyan Wang
Meimei Chen
Original Research 31 July 2017 Pages: 2951 - 2966
Quinoxalin-2(1H)-one derived AMPA-receptor antagonists: Design, synthesis, molecular docking and anticonvulsant activity
Abdel-Ghany A. El-Helby
Rezk R. A. Ayyad
Alaa Elwan
Original Research 04 August 2017 Pages: 2967 - 2984
Design and synthesis of novel triazole linked pyrrole derivatives as potent Mycobacterium tuberculosis inhibitors
M. Lakshmi Devi
P. Lakshmi Reddy
R. Narender
Original Research 05 September 2017 Pages: 2985 - 2999
Identification of potential type 4 cAMP phosphodiesterase inhibitors via 3D pharmacophore modeling, virtual screening, DFT and structural bioisostere design
Dhrubajyoti Gogoi
Amrita K. Chaliha
Alak K. Buragohain
Original Research 09 August 2017 Pages: 3000 - 3014
Novel L-arginine derivatives as aminopeptidase N inhibitors: design, chemistry, and pharmacological evaluation
Jiajia Mou
Yepeng Luan
Qiang Wang
Original Research 16 August 2017 Pages: 3015 - 3025
Analgesic, anti-inflammatory, and antimicrobial activities of novel isoxazole/pyrimidine/pyrazole substituted benzimidazole analogs
Krishna Veni Chikkula
Raja Sundararajan
Original Research 09 August 2017 Pages: 3026 - 3037
Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
Bini Mathew
Judith V. Hobrath
Robert C. Reynolds
Original Research Open access 05 August 2017 Pages: 3038 - 3045
Synthesis, in vitro evaluation of antibacterial, antifungal and larvicidal activities of pyrazole/pyridine based compounds and their nanocrystalline MS (M = Cu and Cd) derivatives
Gopinath Mondal
Harekrishna Jana
Pulakesh Bera
Original Research 24 August 2017 Pages: 3046 - 3056
Synthesis and neuroprotective activity of novel 1,2,4-triazine derivatives with ethyl acetate moiety against H₂O₂ and Aβ-induced neurotoxicity
Tuba Tuylu Kucukkilinc
Kamaledin Safari Yanghagh
Hamid Irannejad
Original Research 04 August 2017 Pages: 3057 - 3071
Erratum to: Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents
G. Jagadeesh Kumar
S. Naveen Kumar
V. Jayathirtha Rao
Erratum 17 July 2017 Pages: 3072 - 3075

Volume 26, Issue 11

Towards the design of 3-aminopyrazole pharmacophore of pyrazolopyridine derivatives as novel antioxidants

Discovery two potent and new inhibitors of 15-lipoxygenase: (E)-3-((3,4-dihydroxybenzylidene) amino)-7-hydroxy-2H-chromen-2-one and (E)-O-(4-(((7-hydroxy-2-oxo-2H-chromen-3-yl) imino)methine) phenyl)dimethylcarbamothioate

Design, synthesis, and docking studies of new 2-benzoxazolinone derivatives as anti-HIV-1 agents

Involvement of reactive oxygen species in the oleoylethanolamide effects and its pyrazonilic analogue in melanoma cells

Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitors

Phytochemical characterization and biological activity of secondary metabolites from three Limonium species

RETRACTED ARTICLE: Rhodozepinone, a new antitrypanosomal azepino-diindole alkaloid from the marine sponge-derived bacterium Rhodococcus sp. UA13

Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities

Docking-based comparative intermolecular contacts analysis and in silico screening reveal new potent acetylcholinesterase inhibitors

Design, synthesis, estrogenic and antiestrogenic activities of some triarylpyrazole derivatives

Choline kinase inhibition and docking studies of a series of 6-(benzylthio)-9H-purin-9-yl-pyridinium derivatives

Liuweibuqi capsules suppress inflammation by affecting T cell polarization and survival in chronic obstructive pulmonary disease

Structure-based rational design of peptide inhibitors to disrupt the recognition and interaction between hepatitis B virus large envelope protein and human hepatocyte receptor γ2-adaptin

Design, synthesis, and biological evaluation of 4-H pyran derivatives as antimicrobial and anticancer agents

Bioguided study of the in vitro parasitocidal effect on adult Hymenolepis nana of the Psidium sartorianum (O. Berg Nied.) fruit methanol extract

Antiproliferative effect of apocynin in cervical epithelial cells infected by HPV 16 involves change of ROS production and cell cycle

Synthesis, cytotoxicity and pro-apoptosis activity of isoquinoline quinones

PTP1B inhibitory and cytotoxic activities of triterpenoids from the aerial parts of Agrimonia pilosa

Design, synthesis and biological evaluation of urea-based benzamides derivatives as HDAC inhibitors

Synthesis, antimycobacterial screening and molecular docking studies of 4-aryl-4′-methyl-2′-aryl-2,5′-bisthiazole derivatives

Isolation of three new metabolites and intervention of diazomethane led to separation of compound 1 & 2 from an endophytic fungus, Cryptosporiopsis sp. depicting cytotoxic activity

Synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine-3-carboxamide as antimicrobial agents

The effects of flavonoid compound from Agrimonia pilosa Ledeb on promotting 3T3-L1 preadipocytes differentiation by activating PPARγ partially

Imatinib derivatives as inhibitors of K562 cells in chronic myeloid leukemia

Antiacetylcholinesterase activity and docking studies with chlorogenic acid, cynarin and arzanol from Helichrysum stoechas (Lamiaceae)

Design, synthesis and CoMFA studies of OEA derivatives as FAAH inhibitors

Quinoxalin-2(1H)-one derived AMPA-receptor antagonists: Design, synthesis, molecular docking and anticonvulsant activity

Design and synthesis of novel triazole linked pyrrole derivatives as potent Mycobacterium tuberculosis inhibitors

Identification of potential type 4 cAMP phosphodiesterase inhibitors via 3D pharmacophore modeling, virtual screening, DFT and structural bioisostere design

Novel L-arginine derivatives as aminopeptidase N inhibitors: design, chemistry, and pharmacological evaluation

Analgesic, anti-inflammatory, and antimicrobial activities of novel isoxazole/pyrimidine/pyrazole substituted benzimidazole analogs

Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens

Synthesis, in vitro evaluation of antibacterial, antifungal and larvicidal activities of pyrazole/pyridine based compounds and their nanocrystalline MS (M = Cu and Cd) derivatives

Synthesis and neuroprotective activity of novel 1,2,4-triazine derivatives with ethyl acetate moiety against H₂O₂ and Aβ-induced neurotoxicity

Erratum to: Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents

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