1. Introduction of the symposium

   • F. Vogel

   EditorialNotes Pages: 5 - 5

2. Spontaneous Mutations in Fungi

   • H. Marquardt

   I. Point Mutations Pages: 7 - 18

3. Spontaneous mutations in bacteria and phages

   • U. Winkler

   I. Point Mutations Pages: 19 - 26

4. Spontaneous mutations in Drosophila melanogaster

   • U. Graf

   I. Point Mutations Pages: 27 - 32

5. Spontaneous frequencies of point mutations in mice

   • A. G. Searle

   I. Point Mutations Pages: 33 - 38

6. Evolutionary adjustment of spontaneous mutation rates

   • R. W. Kaplan

   I. Point Mutations Pages: 39 - 42

7. Comparison of point mutation rates in different species with human mutation rates

   • P. Propping

   I. Point Mutations Pages: 43 - 48

8. Mutator genes in different species

   • G. Mohn
   • F. E. Würgler

   I. Point Mutations Pages: 49 - 58

9. Molecular mechanisms of spontaneous mutations

   • O. L. Klamerth

   I. Point Mutations Pages: 59 - 60

10. Mutation mechanisms in Drosophila

    • F. E. Würgler

    I. Point Mutations Pages: 61 - 66

11. Amino-acid sequences of different species as source of information about mutation mechanisms

    • Walter M. Fitch

    I. Point Mutations Pages: 67 - 69

12. Evidence on the mechanism of spontaneous mutations from human haemoglobin variants and some other proteins

    • F. Vogel

    I. Point Mutations Pages: 71 - 76

13. Human mutations and paternal age

    • W. Tünte

    I. Point Mutations Pages: 77 - 82

14. Ageing of human fibroblasts in culture: Studies on enzymes and mutation

    • Robin Holliday

    I. Point Mutations Pages: 83 - 86

15. The spontaneous azaguanine-resistant mutants of diploid human fibroblasts

    • Robert DeMars
    • Karsten R. Held

    I. Point Mutations Pages: 87 - 110

16. Critical survey

    • W. Lenz

    I. Point Mutations Pages: 111 - 114

17. Frequency of spontaneous chromosome mutations in spermatogenesis of mice

    • E. Schleiermacher

    II. Chromosome Mutations Pages: 115 - 118

18. Chromosomal aneuploidy in human spermatozoa

    • I. H. Pawlowitzki
    • P. L. Pearson

    II. Chromosome Mutations Pages: 119 - 122

19. Frequencies of spontaneous non-disjunction in metaphase II oocytes of mice

    • G. Röhrborn

    II. Chromosome Mutations Pages: 123 - 125

20. Mutation frequency in human oocytes

    • B. Uebele-Kallhardt

    II. Chromosome Mutations Pages: 127 - 129

21. Frequency of chromosome abnormalities in abortions

    • I. H. Pawlowitzki

    II. Chromosome Mutations Pages: 131 - 136

22. Chromosome mutations: Frequency at birth in humans

    • Patricia A. Jacobs

    II. Chromosome Mutations Pages: 137 - 140

23. The effect of maternal age on the incidence of Down's syndrome

    • Margareta Mikkelsen
    • J. Stene

    II. Chromosome Mutations Pages: 141 - 146

24. Satellite association. A possible cause of chromosome aberrations

    • W. Rosenkranz
    • S. Holzer

    II. Chromosome Mutations Pages: 147 - 150

25. Spontaneous chromosomal instability

    • Eberhard Passarge

    II. Chromosome Mutations Pages: 151 - 157

26. Spontaneous chromosome aberrations in human somatic cells

    • N. P. Bochkov

    II. Chromosome Mutations Pages: 159 - 164

27. Diabetes mellitus in patients with aneuploid chromosome aberrations and in their parents

    • Johannes Nielsen

    II. Chromosome Mutations Pages: 165 - 170

28. Immunological aberrations in patients with aneuploid chromosome abnormalities and in their parents

    • Johannes Nielsen

    II. Chromosome Mutations Pages: 171 - 176

29. General discussion

    BriefCommunication Pages: 177 - 177

30. Concluding remarks

    • F. Vogel

    EditorialNotes Pages: 178 - 180