References
Holliday, R., Tarrant, G. M.: Altered enzymes in ageing human fibroblasts. Nature (Lond.) 238, 26 (1972).
Hayflick, L., Moorehead, P. S.: The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585 (1961).
Martin, G., Sprague, C., Epstein, C.: Replicative life-span of cultivated human cells. Lab. Invest. 23, 86 (1970).
Epstein, C. J., Martin, G. M., Schultz, A. L., Motulsky, A. G.: Werner's syndrome: a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural ageing process. Medicine (Baltimore) 45, 177 (1966)
Orgel, L. E.: The maintenance of the accuracy of protein synthesis and its relevance to ageing. Proc. nat. Acid. Sci. (Wash.) 49, 517 (1963).
Langridge, J.: Thermal responses of mutant enzymes and temperature limits to growth. Molec. Gen. Genet. 103, 116 (1968).
Wajntal, A., DeMars, R.: A tetrazolium method for distinguishing between cultured human fibroblasts having either normal or deficient levels of glucose-6-phosphate dehydrogenase. Biochem. Genet. 1, 61 (1967).
Holliday, R.: Errors in protein synthesis and clonal senescense in fungi. Nature (Lond.) 221, 1224 (1969).
Lewis, C. M., Holliday, R.: Mistranslation and ageing in Neurospora. Nature (Lond.) 228, 877 (1970).
Drake, J. W., Preparata, R. M., Allen, E. F., Forsberg, S. A., Greening, E. O.: Genetic control of mutation rates in bacteriophage T4. Nature (Lond.) 221, 1128 (1969).
Tünte, W.: Human mutations and paternal age. Humangenetik 16, 77 (1972).
Vogel, F.: Spontaneous mutation in man. In: Chemical Mutagenesis in Mammals and Man, F. Vogel and G. Röhrborn, Eds. pp. 16–68. Berlin-Heidelberg-New York: Springer 1970.
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Holliday, R. Ageing of human fibroblasts in culture: Studies on enzymes and mutation. Humangenetik 16, 83–86 (1972). https://doi.org/10.1007/BF00393991
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DOI: https://doi.org/10.1007/BF00393991