Guest Editor’s Note: Biostatistics in Preclinical Studies Ludwig A. Hothorn EditorialNotes 30 December 1997 Pages: 321 - 322
Recommendations for Biostatistics of Mutagenicity Studies Dieter HauschkeMakoto HayashiIsao Yoshimura OriginalPaper 30 December 1997 Pages: 323 - 326
Recommendations for Biostatistics of Repeated Toxicity Studies Ludwtg A. HothornK. K. LinW. Rebel OriginalPaper 30 December 1997 Pages: 327 - 334
Statistical Review and Evaluation of In Vitro Mutagenicity Study Data Karl K. Lin ReviewPaper 30 December 1997 Pages: 335 - 344
Issues in the Experimental Design and Statistical Analysis of In Vitro Mutagenicity Tests David P. Lovell OriginalPaper 30 December 1997 Pages: 345 - 356
Statistical Proof of Safety in Toxicological Studies Dieter Hauschke OriginalPaper 30 December 1997 Pages: 357 - 361
The Control of The Consumer Risk in the Ames Assay Markus NeuhäuserLudwig A. Hothorn OriginalPaper 30 December 1997 Pages: 363 - 367
Improving the Efficiency of Fixed-Dose Procedures for the Assessment of Acute Oral Toxicity Nigel StallardAnne Whitehead OriginalPaper 30 December 1997 Pages: 369 - 385
Dose Response Curves for Dichotomous Data: A Bayesian View Paolo Repeto OriginalPaper 30 December 1997 Pages: 387 - 394
How to Achieve Standardization of Statistical Methods in Toxicology Graham F. Healey OriginalPaper 30 December 1997 Pages: 395 - 401
Modifications of the Closure Principle for Analyzing Toxicological Studies Ludwig A. Hothorn OriginalPaper 30 December 1997 Pages: 403 - 412
A Study on the Consistency Between Statistical Evaluation and Toxicological Judgment Chikuma HamadaKei YoshinoMamoru Nomura OriginalPaper 30 December 1997 Pages: 413 - 421
A Performance Comparison of Maximum Contrast Methods to Detect Dose Dependency Isao YoshimuraAkira WakanaChikuma Hamada OriginalPaper 30 December 1997 Pages: 423 - 432
Multivariate Many-to-One Procedures with Applications to Preclinical Trials Siegfried KropfLudwig A. HothornJürgen Läuter OriginalPaper 30 December 1997 Pages: 433 - 447
Power Calculations for General Toxicology Studies Edward J. ChannonAndrew H. Ashley OriginalPaper 30 December 1997 Pages: 449 - 457
Some Notes on the Use of “Exact” Methods In Toxicological Studies Graham Z. Wetherill OriginalPaper 30 December 1997 Pages: 459 - 462
Trend Tests for Dichotomous Endpoints with Application to Carcinogenicity Studies Markus NeuhäuserLudwig A. Hothorn OriginalPaper 30 December 1997 Pages: 463 - 469
An Age-Adjusted Trend Test for the Tumor Incidence Rate for Single-Sacrifice Experiments Ralph L. KodellBruce A. PearceHongshik Ahn OriginalPaper 30 December 1997 Pages: 471 - 487
Analyzing Carcinogenicity Assays without Cause of Death Information Dirk Heck BoldebucakGeorg NeuhausGünter Heimann OriginalPaper 30 December 1997 Pages: 489 - 507
Evolving Statistical Issues in Carcinogenicity Studies M. J. Goddard OriginalPaper 30 December 1997 Pages: 509 - 520
A Sparse Sampling, Mixed Effects Approach to Toxicokinetic Analyses Peter A. GethingPeter T. Daley-Yates OriginalPaper 30 December 1997 Pages: 521 - 527
Testing AUC Dose-Proportionality in Destructive Toxicokinetics R. A. J. Wixley OriginalPaper 30 December 1997 Pages: 529 - 549
Comments on the Statistical Analysis of Toxicokinetic Studies Harry MagerGernot Göller OriginalPaper 30 December 1997 Pages: 551 - 562
Competitive Antagonism in Pharmacology: A Proposed Single Step Evaluation Lisa MaïofissCorinne Thomas-HaimezJean Maccario OriginalPaper 30 December 1997 Pages: 563 - 572
Shelf-Life Estimation for Multifactor Stability Studies James J. ChenHongshik AhnYi Tsong OriginalPaper 30 December 1997 Pages: 573 - 587
Expiration Dating of Pharmaceutical Compounds in Relation to Analytical Variation, Degradation Rate, and Matrix Designs Jaya NatarajanStan AltanDamaraju Raghavarao OriginalPaper 30 December 1997 Pages: 589 - 595
Stavex: A Sophisticated but User-Friendly Expert System for the Design and Analysis of Experiments Wolfgang SeewaldYves-Laurent Grize OriginalPaper 30 December 1997 Pages: 597 - 606
Application of a Continuous-Time Markov Chain to a Preclinical Study Hussein R. Al-KhalidiDaniel J. Schnell OriginalPaper 30 December 1997 Pages: 607 - 613
Application of Adaptive Interim Analysis in Pharmacology Ludwig A. HothornUllrich Martin OriginalPaper 30 December 1997 Pages: 615 - 619