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Application of Adaptive Interim Analysis in Pharmacology

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Abstract

A Drug Information Association Workshop on “Statistical Methodology on Non-Clinical and Toxicological Studies” was held March 25–27, 1996. The purpose of this meeting was to discuss the appropriateness of current and new biostatistical methods in this field of drug development. This paper describes the application of adaptive interim analysis in pharmacological studies. Bauer and Könne (1) published a two-step approach in the case of unknown a priori information. This approach is now widely used for clinical trails. Here, the advantages of use in some pharmacological studies will be discussed.

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Authors and Affiliations

  1. University of Hannover, Herrenhauser Str. 2, D-30419, Hannover, Germany

    Ludwig A. Hothorn PhD

  2. Boehringer Mannheim GmbH, Penzberg, Germany

    Ullrich Martin PhD

Authors
  1. Ludwig A. Hothorn PhD
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  2. Ullrich Martin PhD
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Hothorn, L.A., Martin, U. Application of Adaptive Interim Analysis in Pharmacology. Ther Innov Regul Sci 31, 615–619 (1997). https://doi.org/10.1177/009286159703100229

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