1. Increased protein S-nitrosylation in mitochondria: a key mechanism of exercise-induced cardioprotection

   • Doria Boulghobra
   • Mathilde Dubois
   • Cyril Reboul

   Original Contribution 23 December 2021 Article: 66

   

2. Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia–reperfusion injury

   • Su Li
   • Jinxiang Chen
   • Junbo Ge

   Original Contribution Open access 16 December 2021 Article: 65

   

3. Single-cell transcriptomic identified HIF1A as a target for attenuating acute rejection after heart transplantation

   • Yuan Chang
   • Xiangjie Li
   • Shengshou Hu

   Original Contribution 06 December 2021 Article: 64

   

4. Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes

   • Vladimir Bogdanov
   • Andrew M. Soltisz
   • Sandor Györke

   Original Contribution Open access 28 October 2021 Article: 63

   

5. Cardiac dysfunction from cancer and cancer therapy: new pathways for the prevention of late cardiotoxicity

   • Lars Michel
   • Matthias Totzeck
   • Tienush Rassaf

   Editorial Open access 20 October 2021 Article: 62

   

6. Anthracycline-free tumor elimination in mice leads to functional and molecular cardiac recovery from cancer-induced alterations in contrast to long-lasting doxorubicin treatment effects

   • Stefan Pietzsch
   • Katharina Wohlan
   • Denise Hilfiker-Kleiner

   Original Contribution Open access 20 October 2021 Article: 61

   

7. Effects of remote ischemic preconditioning (RIPC) and chronic remote ischemic preconditioning (cRIPC) on levels of plasma cytokines, cell surface characteristics of monocytes and in-vitro angiogenesis: a pilot study

   • Lars Hummitzsch
   • Karina Zitta
   • Martin Albrecht

   Original Contribution Open access 14 October 2021 Article: 60

   

8. Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy

   • Rohin Francis
   • Jun Chong
   • Derek J. Hausenloy

   Original Contribution Open access 14 October 2021 Article: 59

   

9. Cardiomyocyte Na⁺ and Ca²⁺ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors

   • Bence Hegyi
   • Risto-Pekka Pölönen
   • Donald M. Bers

   Original Contribution Open access 14 October 2021 Article: 58

   

10. Prevention of vascular calcification by the endogenous chromogranin A-derived mediator that inhibits osteogenic transdifferentiation

    • Setareh Orth-Alampour
    • Nathalie Gayrard
    • Joachim Jankowski

    Original Contribution Open access 13 October 2021 Article: 57

    

11. Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function

    • Stefano Comità
    • Saveria Femmino
    • Claudia Penna

    Review Open access 12 October 2021 Article: 56

    

12. Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level

    • Man Rao
    • Xiliang Wang
    • Jiangping Song

    Original Contribution 03 October 2021 Article: 55

    

13. The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy

    • Hualu Zhang
    • Ningzhi Yang
    • Zhelong Xu

    Original Contribution 28 September 2021 Article: 54

    

14. The miR-182/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-β-signalling pathways in an SMC/EC-crosstalk-associated manner

    • Yongyi Bai
    • Jingrong Wang
    • Lan Sun

    Original Contribution 21 September 2021 Article: 53

    

15. IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action

    • Sandrine Lecour
    • Ioanna Andreadou
    • on behalf of the European Union-CARDIOPROTECTION COST ACTION CA16225

    Practical Guideline Open access 13 September 2021 Article: 52

    

16. Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities

    • Jens van de Wouw
    • Jarno J. Steenhorst
    • Daphne Merkus

    Original Contribution Open access 12 September 2021 Article: 51

    

17. Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors

    • Jens van de Wouw
    • Oana Sorop
    • Dirk J. Duncker

    Original Contribution Open access 26 August 2021 Article: 50

    

18. Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases

    • Yuliang Feng
    • Wei Huang
    • Siim Pauklin

    Review Open access 14 August 2021 Article: 49

    

19. LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway

    • Ning Liu
    • Masaharu Kataoka
    • Jinghai Chen

    Original Contribution Open access 11 August 2021 Article: 48

    

20. Atg5 knockdown induces age-dependent cardiomyopathy which can be rescued by repeated remote ischemic conditioning

    • Fangfei Wang
    • Quan He
    • Andrew N. Redington

    Original Contribution 28 July 2021 Article: 47

    

21. Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration

    • Jiao Jiao
    • Shujie He
    • Xiang Cheng

    Original Contribution Open access 24 July 2021 Article: 46

    

22. Intravenous metoprolol during ongoing STEMI ameliorates markers of ischemic injury: a METOCARD-CNIC trial electrocardiographic study

    • Raquel Díaz-Munoz
    • María José Valle-Caballero
    • Borja Ibanez

    Original Contribution 19 July 2021 Article: 45

    

23. Thiol-based redox-active proteins as cardioprotective therapeutic agents in cardiovascular diseases

    • Ioanna Andreadou
    • Panagiotis Efentakis
    • Rainer Schulz

    Review 17 July 2021 Article: 44

    

24. What the HEC happens around the heart during COVID-19?

    • Mirko Trilling

    Editorial Open access 05 July 2021 Article: 43

25. Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants

    • Julian U. G. Wagner
    • Denisa Bojkova
    • Stefanie Dimmeler

    Original Contribution Open access 05 July 2021 Article: 42

    

26. Exercise-induced peptide TAG-23 protects cardiomyocytes from reperfusion injury through regulating PKG–cCbl interaction

    • Zijie Cheng
    • Hao Zhang
    • Lingmei Qian

    Original Contribution Open access 25 June 2021 Article: 41

    

27. Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice

    • Jonas Gregorius
    • Chen Wang
    • Dirk M. Hermann

    Original Contribution Open access 08 June 2021 Article: 40

    

28. Pathogenesis of arrhythmogenic cardiomyopathy: role of inflammation

    • Yen-Nien Lin
    • Ahmed Ibrahim
    • Eugenio Cingolani

    Review 04 June 2021 Article: 39

    

29. AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure

    • Anca Remes
    • Andreas H. Wagner
    • Oliver J. Müller

    Original Contribution Open access 04 June 2021 Article: 38

    

30. The platelet paradox of injury versus protection in myocardial infarction—has it been overlooked?

    • Petra Kleinbongard
    • Ioanna Andreadou
    • Gemma Vilahur

    Editorial Open access 26 May 2021 Article: 37

    

31. Translation of experimental cardioprotective capability of P2Y₁₂ inhibitors into clinical outcome in patients with ST-elevation myocardial infarction

    • Marie V. Hjortbak
    • Kevin K. W. Olesen
    • the CONDI-2/ERIC-PPCI investigators

    Original Contribution 26 May 2021 Article: 36

    

32. Mineralocorticoid receptor blockade normalizes coronary resistance in obese swine independent of functional alterations in K_v channels

    • Adam G. Goodwill
    • Hana E. Baker
    • Shawn B. Bender

    Original Contribution 20 May 2021 Article: 35

    

33. Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?

    • Maaike te Lintel Hekkert
    • Gary Newton
    • Michael D. Schneider

    Original Contribution Open access 20 May 2021 Article: 34

    

34. CAESAR’s legacy: a new era of rigor in preclinical studies of cardioprotection

    • Roberto Bolli

    Editorial Open access 20 May 2021 Article: 33

35. Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke

    • Shereen Nizari
    • Marina Basalay
    • Alexander V. Gourine

    Original Contribution Open access 03 May 2021 Article: 32

    

36. Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects

    • Katie Frenis
    • Johanna Helmstädter
    • Sebastian Steven

    Original Contribution Open access 30 April 2021 Article: 31

    

37. HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype

    • Yanjiao Li
    • Min Dong
    • Jie Liu

    Original Contribution Open access 23 April 2021 Article: 30

    

38. Deoxyribonuclease 1 Q222R single nucleotide polymorphism and long-term mortality after acute myocardial infarction

    • Thomas M. Hofbauer
    • Andreas Mangold
    • Irene M. Lang

    Original Contribution Open access 23 April 2021 Article: 29

    

39. Macrophage depletion in stellate ganglia alleviates cardiac sympathetic overactivation and ventricular arrhythmogenesis by attenuating neuroinflammation in heart failure

    • Dongze Zhang
    • Wenfeng Hu
    • Yu-Long Li

    Original Contribution Open access 21 April 2021 Article: 28

    

40. Cardioprotection by post-conditioning with exogenous triiodothyronine in isolated perfused rat hearts and isolated adult rat cardiomyocytes

    • Helmut Raphael Lieder
    • Felix Braczko
    • Petra Kleinbongard

    Original Contribution Open access 19 April 2021 Article: 27

    

41. Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis

    • Gesine M. Dittrich
    • Natali Froese
    • Joerg Heineke

    Original Contribution Open access 19 April 2021 Article: 26

    

42. SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation

    • Natalie M. Landry
    • Sunil G. Rattan
    • Ian M. C. Dixon

    Original Contribution Open access 13 April 2021 Article: 25

    

43. Omecamtiv mecarbil evokes diastolic dysfunction and leads to periodic electromechanical alternans

    • Gábor Á. Fülöp
    • Attila Oláh
    • Attila Tóth

    Original Contribution Open access 12 April 2021 Article: 24

    

44. Cytokines as therapeutic targets for cardio- and cerebrovascular diseases

    • Luca Liberale
    • Stefano Ministrini
    • Fabrizio Montecucco

    Review Open access 26 March 2021 Article: 23

    

45. Adenosine and adenosine receptor-mediated action in coronary microcirculation

    • Ying Zhang
    • Bernhard Wernly
    • Zhichao Zhou

    Review Open access 23 March 2021 Article: 22

    

46. Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning

    • Christine Hirschhäuser
    • Alessio Lissoni
    • Kerstin Boengler

    Original Contribution Open access 22 March 2021 Article: 21

    

47. Cardioprotection vs. regeneration: the case of extracellular vesicle-derived microRNAs

    • Kai C. Wollert
    • Loren J. Field

    Editorial Open access 19 March 2021 Article: 20

48. miR-106a–363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury

    • Ji-Hye Jung
    • Gentaro Ikeda
    • Phillip C. Yang

    Original Contribution 19 March 2021 Article: 19

    

49. Cardiomyocyte depolarization triggers NOS-dependent NO transient after calcium release, reducing the subsequent calcium transient

    • Matias Mosqueira
    • Roland Konietzny
    • Rainer H.A. Fink

    Original Contribution Open access 17 March 2021 Article: 18

    

50. A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

    • Patrick M. Siegel
    • István Bojti
    • Philipp Diehl

    Original Contribution Open access 15 March 2021 Article: 17