1. Introduction

   • Luigi D. Notarangelo

   EditorialNotes Pages: 363 - 367

2. X-linked agammaglobulinemia: lack of mature B lineage cells caused by mutations in the Btk kinase

   • C. I. Edvard Smith
   • Carl-Magnus Bäckesjö
   • Mauno Vihinen

   OriginalPaper Pages: 369 - 381

3. The hyper-IgM (HIM) syndrome

   • Narayanaswamy Ramesh
   • Makoto Seki
   • Raif S. Geha

   OriginalPaper Pages: 383 - 399

4. Severe combined immune deficiencies due to defects of the common γ chain-JAK3 signaling pathway

   • Fabio Candotti
   • John J. O'Shea
   • Anna Villa

   OriginalPaper Pages: 401 - 415

5. The molecular basis of chronic granulomatous disease

   • Christof Meischl
   • Dirk Roos

   OriginalPaper Pages: 417 - 434

6. The Wiskott-Aldrich syndrome

   • Hans D. Ochs

   OriginalPaper Pages: 435 - 458

7. Lymph node pathology in primary combined immunodeficiency diseases

   • Fabio Facchetti
   • Laura Blanzuoli
   • William Vermi

   OriginalPaper Pages: 459 - 478

8. Stem cell transplantation for immunodeficiency

   • A. Fischer
   • E. Haddad
   • M. Cavazzana-Calvo

   OriginalPaper Pages: 479 - 492

9. Gene therapy of primary immunodeficiencies

   • Fabio Candotti
   • R. Michael Blaese

   OriginalPaper Pages: 493 - 508