CRISPR-Cas9 system, the next generation in cancer therapy and target discovery

In this topical collection (8 articles)

1. Research

   Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment

   Liliana R. Loureiro, Lydia Hoffmann… Article:341

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2. Review

   CRISPR/Cas9: a powerful tool in colorectal cancer research

   Yang Hu, Liang Liu, Qi Jiang, Weiping Fang… Article:308

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3. Research

   A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity

   Dong-hee Lee, Hyejin Ahn, Hye-In Sim… Article:272

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4. Research

   CRISPR-Cas9 knockout screening identifies KIAA1429 as an essential gene in Ewing sarcoma

   Kezhe Tan, Wenjie Lu, Feng Chen, Hao Shi… Article:250

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5. Research

   CHSY1 promotes CD8⁺ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening

   Guangshun Sun, Siqi Zhao, Zhongguo Fan… Article:248

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6. Research

   CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma

   Tsutomu Nakazawa, Takayuki Morimoto… Article:205

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7. Research

   Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening

   Xing Li, Shiyu Sun, Wansong Zhang… Article:95

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8. Review

   GMP-manufactured CRISPR/Cas9 technology as an advantageous tool to support cancer immunotherapy

   M Caforio, S Iacovelli, C Quintarelli… Article:66

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