1. Millenial rheumatology

   • Bruce N. Cronstein

   Invited Commentary Pages: 1 - 2

2. Web alert

   • Stefano Fiore

   News Pages: 3 - 4

3. Literature alert

   • Arturo Diaz
   • Clifton O. Bingham III

   Abstract Pages: 5 - 9

4. Clinical trials for the treatment of systemic sclerosis/scleroderma

   • John Varga
   • Ileana Ponor

   Clinical Trials Review Pages: 13 - 14

5. Microchimerism and scleroderma

   • J. Lee Nelson

   OriginalPaper Pages: 15 - 21

6. Novel therapeutic strategies in scleroderma

   • Christopher P. Denton
   • Carol M. Black

   OriginalPaper Pages: 22 - 27

7. Integrin signaling in fibrosis and scleroderma

   • Humphrey A. Gardner

   OriginalPaper Pages: 28 - 33

8. Genetic and immunologic features associated with scleroderma-like syndrome of TSK mice

   • Shinchiro Saito
   • Kuppuswamy Kasturi
   • Constantin Bona

   OriginalPaper Pages: 34 - 37

9. Penicillamine in the treatment of systemic sclerosis

   • Philip J. Clements

   OriginalPaper Pages: 38 - 42

10. Osteoarthritis

    • Lee S. Simon

    Clinical Trials Review Pages: 45 - 47

11. Nonpharmacologic therapy of osteoarthritis

    • Philip J. Perkins
    • Michael Doherty

    OriginalPaper Pages: 48 - 53

12. Pharmacologic therapy of osteoarthritis

    • Jean-Pierre Pelletier
    • Denis Choquette
    • Johanne Martel-Pelletier

    OriginalPaper Pages: 54 - 58

13. Clinical assessment and significance of inflammation in knee osteoarthritis

    • V. T. Baddour
    • J. D. Bradley

    OriginalPaper Pages: 59 - 63

14. Cytokines and the immunopathology of the spondyloarthropathies

    • Jürgen Braun
    • Joachim Sieper

    OriginalPaper Pages: 67 - 77

15. A molecular insight on the association of HLA-B27 with spondyloarthropathies

    • Mercè Martí
    • Iñaki Álvarez
    • José A. López de Castro

    OriginalPaper Pages: 78 - 85