1. Firing Up the Innovation Engine

   Editorial Pages: 1 - 1

2. SNIDD Special Issue

   • H. Donald Burns
   • Richard A. Frank
   • Rikki Waterhouse

   Editorial Pages: 2 - 4

3. Molecular Imaging in Drug Discovery and Development: Potential and Limitations of Nonnuclear Methods

   • Markus Rudin
   • Martin Rausch
   • Markus Stoeckli

   Review Article Pages: 5 - 13

   

4. What Has Intrinsic Signal Optical Imaging Taught Us About NGF-Induced Rapid Plasticity in Adult Cortex and Its Relationship to the Cholinergic System?

   • Neal Prakash
   • Ron D. Frostig

   Review Article Pages: 14 - 21

   

5. Noninvasive Imaging of Cardiac Gene Expression and Its Future Implications for Molecular Therapy

   • Frank M. Bengel

   Review Article Pages: 22 - 29

   

6. Weaving Single Photon Imaging into New Drug Development

   • P. David Mozley

   Review Article Pages: 30 - 36

7. Positron Emission Tomography Studies on Binding of Central Nervous System Drugs and P-Glycoprotein Function in the Rodent Brain

   • Philip H. Elsinga
   • N. Harry Hendrikse
   • Willem Vaalburg

   Review Article Pages: 37 - 44

   

8. Imaging the Dopamine System with In Vivo [¹¹C]raclopride Displacement Studies: Understanding the True Mechanism

   • Nathalie Ginovart

   Review Article Pages: 45 - 52

9. Positron Emission Tomography Imaging of Small Animals in Anticancer Drug Development

   • Eric O. Aboagye

   Review Article Pages: 53 - 58

   

10. Toward the Validation of Functional Neuroimaging as a Potential Biomarker for Alzheimer’s Disease: Implications for Drug Development

    • Alberto Pupi
    • Lisa Mosconi
    • Sandro Sorbi

    Review Article Pages: 59 - 68

    

11. A Computational Positron Emission Tomography Simulation Model for Imaging β-Amyloid in Mice

    • Melvin K. Simmons
    • Ravindra Manjeshwar
    • Michael C. Montalto

    Review Article Pages: 69 - 77