1. Editorial

   • Charles Kennedy

   Editorial 04 January 2021 Pages: 167 - 167

2. A novel mechanism of rotavirus infection involving purinergic signaling

   • Wilmarie Morales-Soto
   • Brian D. Gulbransen

   Journal Club Open access 18 February 2021 Pages: 169 - 171

3. Pancreatic cancer immune evasion mechanisms: the immunosuppressive role of P2RX1-negative neutrophils

   • Valentina Audrito

   Journal Club 30 March 2021 Pages: 173 - 174

4. P2X7: a receptor with a split personality that raises new hopes for anti-cancer therapy

   • Alba Clara Sarti
   • Valentina Vultaggio-Poma
   • Francesco Di Virgilio

   Journal Club Open access 05 April 2021 Pages: 175 - 178

5. Targeting the purinergic pathway in breast cancer and its therapeutic applications

   • Julia Beatrice de Araújo
   • Vanessa Vitória Kerkhoff
   • Débora Tavares de Resende e Silva

   Review Article 12 February 2021 Pages: 179 - 200

   

6. Contribution of P2X4 receptor in pain associated with rheumatoid arthritis: a review

   • Nurul Ajilah Mohamed Khir
   • Ain’ Sabreena Mohd Noh
   • Che Aishah Nazariah Ismail

   Review Article 17 February 2021 Pages: 201 - 213

   

7. Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer

   • Matthew Drill
   • Nigel C. Jones
   • Mastura Monif

   Review Article 17 March 2021 Pages: 215 - 227

   

8. Targeting P2 receptors in purinergic signaling: a new strategy of active ingredients in traditional Chinese herbals for diseases treatment

   • Xiaopeng Ai
   • Xing Dong
   • Xiaobo Wang

   Review Article 22 March 2021 Pages: 229 - 240

9. Bone phenotype of P2X4 receptor knockout mice: implication of a P2X7 receptor mutation?

   • Maria Ellegaard
   • Tanja Hegner
   • Niklas Rye Jørgensen

   Brief Communication 15 April 2021 Pages: 241 - 246

   

10. Adenosine A₁ and A_2A receptors are involved on guanosine protective effects against oxidative burst and mitochondrial dysfunction induced by 6-OHDA in striatal slices

    • C. M. Massari
    • L. C. Constantino
    • C. I. Tasca

    Original Article 06 February 2021 Pages: 247 - 254

    

11. Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke

    • Gabriel C. Müller
    • Samanta O. Loureiro
    • Diogo O. Souza

    Original Article 09 April 2021 Pages: 255 - 271

    

12. Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth

    • Daniela Vasconcelos Lopes
    • Amanda de Fraga Dias
    • Fabrício Figueiró

    Original Article 20 March 2021 Pages: 273 - 284

    

13. Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling

    • Priscila B. Rosa
    • Luis E. B. Bettio
    • Ana Lúcia S. Rodrigues

    Original Article 13 March 2021 Pages: 285 - 301

    

14. The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior

    • S. J. Macedo-Júnior
    • F. P. Nascimento
    • A. R. S. Santos

    Original Article 16 April 2021 Pages: 303 - 312

    

15. What strikes most when we think of Geoff

    • Cinzia Volonté

    Letter 03 March 2021 Pages: 313 - 313

    

16. Correction to: The history of the purine Club: a tribute to prof. Geoffrey Burnstock

    • Maria P. Abbracchio

    Correction 13 April 2021 Pages: 315 - 315