Validation of Bioanalytical Methods H. Thomas KarnesGerald ShiuVinod P. Shah ReviewPaper Pages: 421 - 426
The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone Michael J. PikalKaren M. DellermanRalph M. Riggin OriginalPaper Pages: 427 - 436
Hepatic Disposition Characteristics of Electrically Charged Macromolecules in Rat in Vivo and in the Perfused Liver Koyo NishidaKiyoshi MiharaHitoshi Sezaki OriginalPaper Pages: 437 - 444
Colon-Specific Delivery of Dexamethasone from a Glucoside Prodrug in the Guinea Pig Thomas N. TozerJean RigodDavid R. Friend OriginalPaper Pages: 445 - 454
Amine Prodrugs Which Utilize Hydroxy Amide Lactonization. II. A Potential Esterase-Sensitive Amide Prodrug Kent L. AmsberryA. Elise GerstenbergerRonald T. Borchardt OriginalPaper Pages: 455 - 461
Molecular Structure and Dynamics of cis(Z)- and trans(E)-Flupenthixol and Clopenthixol Ingebrigt SylteSvein G. Dahl OriginalPaper Pages: 462 - 470
Effects of Viscous Hyaluronate–Sodium Solutions on the Nasal Absorption of Vasopressin and An Analogue Kazuhiro MorimotoHiroshi YamaguchiYoshiki Nakai OriginalPaper Pages: 471 - 474
In Vitro Evaluation of the Plasma and Blood Compatibility of a Parenteral Formulation for Ditekiren, a Novel Renin Inhibitor Pseudopeptide John C. GreenfieldSheryl J. LouxStephen R. Davio OriginalPaper Pages: 475 - 479
Inactivation Kinetics of Enzyme Pharmaceuticals in Aqueous Solution Sumie YoshiokaKen-ichi IzutsuYasushi Takeda OriginalPaper Pages: 480 - 484
Stability of Interleukin 1β (IL-1β) in Aqueous Solution: Analytical Methods, Kinetics, Products, and Solution Formulation Implications Leo C. GuElizabeth A. ErdösLinda C. Foster OriginalPaper Pages: 485 - 490
Effect of Polyethylene Glycol 400 on the Intestinal Permeability of Carbamazepine in the Rabbit Lillian E. RiadRonald J. Sawchuk OriginalPaper Pages: 491 - 497
Effects of Deoxycholate on the Transepithelial Transport of Sucrose and Horseradish Peroxidase in Filter-Grown Madin–Darby Canine Kidney (MDCK) Cells Yi-Jing LinWei-Chiang Shen OriginalPaper Pages: 498 - 501
Cosolvency of Dimethyl Isosorbide for Steroid Solubility Hossein ZiaJoseph K. H. MaLouis A. Luzzi OriginalPaper Pages: 502 - 504
Molecular Motion of Drugs in Hydrocolloids Measured by Electron Paramagnetic Resonance Julijana KristlSlavko PečarMilan Schara OriginalPaper Pages: 505 - 507
Mean Residence Times and Distribution Volumes for Drugs Undergoing Linear Reversible Metabolism and Tissue Distribution and Linear or Nonlinear Elimination from the Central Compartments Haiyung ChengWilliam J. Jusko OriginalPaper Pages: 508 - 511
Suitability of Various Noninfinity Area Under the Plasma Concentration–Time Curve (AUC) Estimates for Use in Bioequivalence Determinations: Relationship to AUC from Zero to Time Infinity (AUCO–INF) Marilyn N. MartinezAndre J. Jackson OriginalPaper Pages: 512 - 517
The Preparation and Evaluation of a Tablet Dosage Form of Cyclosporine in Dogs Hisham Y. AbdallahMichael Mayersohn OriginalPaper Pages: 518 - 522
High-Performance Liquid Chromatographic (HPLC) Determination of Lobenzarit in Plasma and Its Application to a Bioavailability Study in Beagle Dogs Francis J. SchwendeScott W. Turner OriginalPaper Pages: 523 - 526
Synthesis of Poly(Hydroxypropylglutamine-Prazosin Carbamate) and Release Studies Xiaoling LiNathan W. AdamsSung Wan Kim OriginalPaper Pages: 527 - 530
“On–Off” Thermocontrol of Solute Transport. I. Temperature Dependence of Swelling of N-Isopropylacrylamide Networks Modified with Hydrophobic Components in Water You Han BaeTeruo OkanoSung Wan Kim OriginalPaper Pages: 531 - 537
In Vitro Binding of Lorazepam and Lorazepam Glucuronide to Cholestyramine, Colestipol, and Activated Charcoal Robert J. HermanArchana Chaudhary Note Pages: 538 - 540
Determination of the Relative Formation and Elimination Clearance of Two Major Carbamazepine Metabolites in Humans: A Comparison Between Traditional and Pooled Sample Analysis Lillian E. RiadKeith K. ChanRonald J. Sawchuk Note Pages: 541 - 543
Drug Metabolism and Laboratory Anesthetic Protocols in the Rat: Examination of Antipyrine Pharmacokinetics Mark GumbletonLeslie Z. Benet Note Pages: 544 - 546
Rapid High-Performance Liquid Chromatographic Analysis and Stability Study of Hydrocortisone 17-Butyrate in Cream Preparations Sompon Wanwimolruk Note Pages: 547 - 549