Solid-State Phase Transitions Initiated by Water Vapor Sorption of Crystalline L-660,711, a Leukotriene D4 Receptor Antagonist Elizabeth B. VadasPascal TomaGeorge Zografi OriginalPaper Pages: 148 - 155
Design and Manufacture of a Zero-Order Sustained-Release Pellet Dosage Form Through Nonuniform Drug Distribution in a Diffusional Matrix Douglas C. ScottR. Gary Hollenbeck OriginalPaper Pages: 156 - 161
Extent and Variability of the First-Pass Elimination of Adinazolam Mesylate in Healthy Male Volunteers Joseph C. FleishakerH. FriedmanSteven R. Pollock OriginalPaper Pages: 162 - 167
A Method to Study Drug Concentration–Depth Profiles in Tissues: Mitomycin C in Dog Bladder Wall M. Guillaume WientjesJames T. DaltonJessie L.-S. Au OriginalPaper Pages: 168 - 173
Synthesis and in Vitro Receptor Binding Studies of Fluorotamoxifen Analogues David J. YangSidney WallaceE. Edmund Kim OriginalPaper Pages: 174 - 177
Polymorphic Behavior of Sprayed Lipid Micropellets and Its Evaluation by Differential Scanning Calorimetry and Scanning Electron Microscopy Türkan EldemPeter SpeiserHans Altorfer OriginalPaper Pages: 178 - 184
In Vitro Release Profile of Mitomycin C from Albumin Microspheres: Extrapolation from Macrospheres to Microspheres Hideshi NatsumeKenji SugibayashiYasunori Morimoto OriginalPaper Pages: 185 - 190
Water Vapor Adsorption and Desorption Isotherms of Biologically Active Proteins C. Diana TengM. Hossein ZarrintanMichael J. Groves OriginalPaper Pages: 191 - 195
Opioid-Induced Respiratory Depression and Analgesia May Be Mediated by Different Subreceptors Enno FreyeMartina SchnitzlerGustav Schenk OriginalPaper Pages: 196 - 199
High-Affinity [3H]THA (Tetrahydroaminoacridine) Binding Sites in Rat Brain E. Edward MenaManoj C. Desai OriginalPaper Pages: 200 - 203
Influence of Ultrasound on the Percutaneous Absorption of Nicotinate Esters Heather A. E. BensonJames C. McElnayJonathan Hadgraft OriginalPaper Pages: 204 - 209
A Model of Human Small Intestinal Absorptive Cells. 1. Transport Barrier J. Nita CogburnMatthew G. DonovanCharles S. Schasteen OriginalPaper Pages: 210 - 216
Nebulization of Liposomes. II. The Effects of Size and Modeling of Solute Release Profiles Ralph W. NivenMelissa SpeerHans Schreier OriginalPaper Pages: 217 - 221
Characterization of the Unstirred Water Layer in Caco-2 Cell Monolayers Using a Novel Diffusion Apparatus Ismael J. HidalgoKathleen M. HillgrenRonald T. Borchardt OriginalPaper Pages: 222 - 227
Model Selection for the Adsorption of Phenobarbital by Activated Charcoal Gerald M. BurkeDale Eric WursterDorothy D. Schottelius OriginalPaper Pages: 228 - 231
Computer-Aided Dosage Form Design. III. Feasibility Assessment for an Oral Prolonged-Release Phenytoin Product Joy R. IrvinRobert E. Notari OriginalPaper Pages: 232 - 237
Effect of Competing Anions on Binding of Bile Salts by Cholestyramine Rosemary KosJoe L. WhiteMarie T. Borin OriginalPaper Pages: 238 - 241
Sulfate Homeostasis. III. Effect of Chronic Naproxen or Sulindac Treatment on Inorganic Sulfate Disposition in Arthritic Patients with Renal Impairment Marilyn E. MorrisJack P. FreerWilliam A. Watson OriginalPaper Pages: 242 - 246
Hybrid Pharmacokinetic Models to Describe Anti-HIV Nucleoside Brain Disposition Following Parent and Prodrug Administration in Mice James M. GalloJoseph T. EtseChung K. Chu OriginalPaper Pages: 247 - 253
Simple Methods for Estimation of Mean Residence Time and Steady-State Volume of Distribution from Continuous-Infusion Data William R. Gillespie OriginalPaper Pages: 254 - 258
Stereoselective Transport of Baclofen Across the Blood–Brain Barrier in Rats as Determined by the Unit Impulse Response Methodology Joost B. M. M. van BreeCorrie D. Heijligers-FeijenDouwe D. Breimer OriginalPaper Pages: 259 - 262
Pharmacodynamics of Methylprednisolone Phosphate After Single Intravenous Administration to Healthy Volunteers Hartmut DerendorfHelmut MöllmannHans-Jürgen Röthig OriginalPaper Pages: 263 - 268
Simplified Determination of Antipyrine Clearance by Liquid Chromatography of a Microsample of Saliva or Plasma Adnan El-YazigiDale A. RainesMartin Dossing OriginalPaper Pages: 269 - 272
Protection Against Microcystin-LR-Induced Hepatotoxicity by Silymarin: Biochemistry, Histopathology, and Lethality Kay A. MereishDavid L. BunnerDonald A. Creasia OriginalPaper Pages: 273 - 277
Prediction of Acute Graft Rejection in Renal Transplantation: The Utility of Cyclosporine Blood Concentrations Joachim GrevelKimberly L. NapoliBarry D. Kahan OriginalPaper Pages: 278 - 281
The Relationship Between Urine and Plasma Concentrations of Carbamazepine: Implications for Therapeutic Drug Monitoring William F. ElmquistLillian E. RiadRonald J. Sawchuk Note Pages: 282 - 284
