News from the National Institute of General Medical Sciences (NIGMS) Rochelle M. Long News Pages: 339 - 341
Pharmacogenetics as a Molecular Basis for Individualized Drug Therapy: The Thiopurine S-methyltransferase Paradigm Eugene Y. KrynetskiWilliam E. Evans ReviewPaper Pages: 342 - 349
The Effect of Formulation Excipients on Protein Stability and Aerosol Performance of Spray-Dried Powders of a Recombinant Humanized Anti-IgE Monoclonal Antibody1 James D. AndyaYuh-Fun MaaSteven J. Shire OriginalPaper Pages: 350 - 358
Degradation and Aggregation of Human Calcitonin In Vitro Richard H. LuPavla KopečkováJindřich Kopeček OriginalPaper Pages: 359 - 367
Real Time Detection of Photoreactivity in Pharmaceutical Solids and Solutions with Isothermal Microcalorimetry Vesa-Pekka LehtoJarno SalonenEnsio Laine OriginalPaper Pages: 368 - 373
Multiwavelength Spectrophotometric Determination of Acid Dissociation Constants: Part II. First Derivative vs. Target Factor Analysis K. Y. TarnK. Takács-Novák OriginalPaper Pages: 374 - 381
In Vitro Evaluation of Microparticles and Polymer Gels for Use as Nasal Platforms for Protein Delivery Claudia WitschiRandall J. Mrsny OriginalPaper Pages: 382 - 390
Evidence for Overlapping Substrate Specificity Between Large Neutral Amino Acid (LNAA) and Dipeptide (hPEPTl) Transporters for PD 158473, an NMDA Antagonist Narayanan SurendranKuang-Ming Y. CovitzBarbra H. Stewart OriginalPaper Pages: 391 - 395
Inhibition of Multidrug Resistance-Associated Protein (MRP) Functional Activity with Pluronic Block Copolymers Donald W. MillerElena V. BatrakovaAlexander V. Kabanov OriginalPaper Pages: 396 - 401
Evidence for Different ABC-Transporters in Caco-2 Cells Modulating Drug Uptake Heike GutmannGert FrickerJürgen Drewe OriginalPaper Pages: 402 - 407
Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein Richard B. KirnChristoph WandelGrant R. Wilkinson OriginalPaper Pages: 408 - 414
Blood-Brain Barrier Transport of Reduced Folic Acid Dafang WuWilliam M. Pardridge OriginalPaper Pages: 415 - 419
Radiolabeled Cholesteryl lopanoate/ Acetylated Low Density Lipoprotein as a Potential Probe for Visualization of Early Atherosclerotic Lesions in Rabbits W. XiaoL. WangH. Liu OriginalPaper Pages: 420 - 426
Self Promotion of Deep Tissue Penetration and Distribution of Methylsalicylate After Topical Application Sheree E. CrossStella A. MegwaMichael S. Roberts OriginalPaper Pages: 427 - 433
In Vitro and In Situ Permeability of a 'Second Generation' Hydroxypyridinone Oral Iron Chelator: Correlation with Physico-Chemical Properties and Oral Activity Nicholas LowtherRoy FoxHarry Donnelly OriginalPaper Pages: 434 - 440
Automated Absorption Assessment Using Caco-2 Cells Cultured on Both Sides of Polycarbonate Membranes Per GarbergPeder ErikssonBrita Sjöström OriginalPaper Pages: 441 - 445
Evaluation of Viability of Excised Rat Intestinal Segments in the Ussing Chamber: Investigation of Morphology, Electrical Parameters, and Permeability Characteristics Britta I. PolentaruttiAnders L. PetersonAnna-Lena B. Ungell OriginalPaper Pages: 446 - 454
Poor and Unusually Prolonged Oral Absorption of Amphotericin B in Rats Gabriel RobbieTa-Chen WuWin L. Chiou BriefCommunication Pages: 455 - 458
Changes in Skin A.C. Impedance Parameters In Vivo During the Percutaneous Absorption of Local Anesthetics A. D. WoolfsonG. P. MossE. T. McAdams BriefCommunication Pages: 459 - 462
ZTTA, a Prolyl Endopeptidase Inhibitor, Potentiates the Arginine-Vasopressin-Induced Incorporation of [14C]Leucine in Rat Amygdaloid and Cortical Slices Yoshiyuki ShishidoTakeshi TanakaShigenori Watanabe BriefCommunication Pages: 463 - 465
Cerebroside-β-Glucosidase Encapsulation in Liposomes for Gaucher's Disease Treatment Revisited Veronica KorablyovAvi ZimranYechezkel Barenholz BriefCommunication Pages: 466 - 469
Development and Application of a Simple Assay to Quantify Cellular Adducts of Platinum Complexes with DNA Charlotte KloftChristiane EickhoffUlrich Jaehde BriefCommunication Pages: 470 - 473