Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives Mohamed Ahmed Mahmoud Abdel ReheimIbrahim Saad Abdel HafizHend Saad Eldin Abdel Rady Original Article Open access 05 January 2021 Pages: 741 - 755
Molecular dynamics-guided receptor-dependent 4D-QSAR studies of HDACs inhibitors Zhihao HuQianxia LinGuogang Tu Original Article 24 February 2021 Pages: 757 - 768
Design, synthesis, and preliminary pharmacological evaluation of novel thiazolidinone derivatives as potential benzodiazepine agonists Ali AlmasiradMaryam GhadimiMehrdad Faizi Original Article 23 January 2021 Pages: 769 - 780
Synthesis of novel antioxidant and antitumor 5-aminopyrazole derivatives, 2D/3D QSAR, and molecular docking Ahmed FekriEman M. KeshkIsraa Taha Original Article 08 March 2021 Pages: 781 - 800
Synthesis and fungicidal activity of methyl (E)-1-(2-((E)-2-methoxy-1-(methoxyimino)-2-oxoethyl)benzyl)-2-(1-arylidene)hydrazine-1-carboxylates †‡ Xuelian LiuChangqing JiaZhaohai Qin Original Article 06 February 2021 Pages: 801 - 813
Friedel–Crafts synthesis of bis(trifluoromethylated)-4-aryl-3,4-dihydroquinazolines, bis(trifluoromethylated)-3,4-dihydroquinazoline-4-ols and trifluoromethyl arylketoimines using N-aryltrifluoroacetimidoyl chlorides and benzene derivatives Elham KazemiAli DarehkordiAlireza Abbasi Original Article 03 February 2021 Pages: 815 - 825
Synthesis, molecular docking studies, and in vitro antimicrobial evaluation of piperazine and triazolo-pyrazine derivatives Mahadev PatilAnurag Noonikara-PoyilAlejandro Bugarin Original Article 05 February 2021 Pages: 827 - 841
Efficient one-pot synthesis of substituted diphenyl 1, 3-thiazole through multicomponent reaction by using green and efficient Iron-catalyst via Cross-Dehydrogenative Coupling(CDC) Manjit SinghVijay B. YadavI. R. Siddiqui Original Article 08 February 2021 Pages: 843 - 848
Dihydroquinazolin-4(1H)-one derivatives as novel and potential leads for diabetic management Oluwatoyin BabatundeShehryar HameedShahnaz Perveen Original Article 01 March 2021 Pages: 849 - 868
Mechanistic insight of cell anti-proliferative activity of fluoroquinolone drug-based Cu(II) complexes Divyang H. GandhiForam U. VaidyaBhupesh S. Bhatt Original Article 01 March 2021 Pages: 869 - 878
TFA-mediated synthesis of functionalized pyrano[2,3-c]pyrazoles from pyrazol-3-ones, active carbonyl compounds and tert-BuOH Issa YavariJamil Sheykhahmadi Original Article 02 March 2021 Pages: 879 - 890
Green synthesis and biological activities assessment of some new chromeno[2,3-b]pyridine derivatives Davood AzarifarMasoumeh GhaemiFatemeh Ghasemlou Original Article 16 April 2021 Pages: 891 - 902
CHK1 kinase inhibition: identification of allosteric hits using MD simulations, pharmacophore modeling, docking and MM-PBSA calculations Nizar Al-Shar’iSondos S. Musleh Original Article 08 March 2021 Pages: 903 - 921
Dimroth rearrangement-based synthesis of novel derivatives of [1,3]selenazolo[5,4-e][1,2,4]triazolo[1,5-c]pyrimidine as a new class of selenium-containing heterocyclic architecture Seddigheh Sheikhi-MohammarehAli ShiriJoel Mague Original Article 15 March 2021 Pages: 923 - 937
Vitamin C and Vitamin D3 show strong binding with the amyloidogenic region of G555F mutant of Fibrinogen A alpha-chain associated with renal amyloidosis: proposed possible therapeutic intervention Monu PandeDebanjan KunduRagini Srivastava Original Article 12 March 2021 Pages: 939 - 949
Design, synthesis and fungicidal activity of 3,4-dichloroisothiazolocoumarin-containing strobilurins You LvKun LiZhijin Fan Original Article 29 March 2021 Pages: 951 - 961
Simultaneous ultrasound- and microwave-assisted one-pot ‘click’ synthesis of 3-formyl-indole clubbed 1,2,3-triazole derivatives and their biological evaluation Jaydeep A. MokariyaAnirudhdha G. KalolaManish P. Patel Original Article 08 April 2021 Pages: 963 - 979
Design and synthesis of small molecular 2-aminobenzoxazoles as potential antifungal agents against phytopathogenic fungi Lingling FanZhongfu LuoYong Li Original Article 03 April 2021 Pages: 981 - 992
One-pot parallel synthesis of 1,3,5-trisubstituted 1,2,4-triazoles Dmytro S. RadchenkoVasyl S. NaumchykOleksandr O. Grygorenko Original Article 02 April 2021 Pages: 993 - 1004
Potential inhibitors of methionine aminopeptidase type II identified via structure-based pharmacophore modeling Safana AlbayatiAbdullahi Ibrahim UbaKemal Yelekçi Original Article 13 April 2021 Pages: 1005 - 1016
QSAR analysis of 3-pyrimidin-4-yl-oxazolidin-2-one derivatives isocitrate dehydrogenase inhibitors using Topomer CoMFA and HQSAR methods Jian-Bo TongShuai BianDing Luo Original Article 11 May 2021 Pages: 1017 - 1037
Synthesis of new 2-aminothiazolyl/benzothiazolyl-based 3,4-dihydropyrimidinones and evaluation of their effects on adenocarcinoma gastric cell migration Mohsen SaghaFatemeh MousaeiNima Razzaghi-Asl Original Article 29 May 2021 Pages: 1039 - 1051
In silico analysis and identification of antiviral coumarin derivatives against 3-chymotrypsin-like main protease of the novel coronavirus SARS-CoV-2 Rahman AbdizadehFarzin HadizadehTooba Abdizadeh Original Article 02 July 2021 Pages: 1053 - 1076
Phosphorus–nitrogen compounds: part 53—synthesis, characterization, cytotoxic and antimicrobial activity, DNA interaction and molecular docking studies of new mono- and dispirocyclotriphosphazenes with pendant arm(s) Özlem İşcanReşit CemaloğluTuncer Hökelek Original Article 14 May 2021 Pages: 1077 - 1100
Estimation of the reducing power and electrochemical behavior of few flavonoids and polyhydroxybenzophenones substantiated by bond dissociation energy: a comparative analysis Madhu Sudan DuttaPrithwish MahapatraSoumalee Basu Original Article 16 May 2021 Pages: 1101 - 1113
Rapid synthetic approaches to libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones and 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones Roman N. VydzhakSvitlana Ya. PanchishinVolodymyr S. Brovarets Original Article 04 June 2021 Pages: 1115 - 1128
New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo Tian-Yi ZhangChun-Shi LiSi-Mei Sun Original Article 02 June 2021 Pages: 1129 - 1139
Reverse orientation in the ultrasound-assisted [3 + 2]-cycloaddition reaction of nitrile imines with 3-formylchromone-Meldrum’s acid adducts Issa YavariYounes Fadakar Original Article 15 June 2021 Pages: 1141 - 1150
A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway Kai YuJie YangLiangzhi Wang Original Article 09 June 2021 Pages: 1151 - 1159
Synthesis and potent antimicrobial activity of novel coumarylthiazole α-aminophosphonates derivatives Bilal LitimZinelaabidine CheraietAbbes Boukhari Original Article 12 June 2021 Pages: 1161 - 1174
Investigating the active compounds and mechanism of HuaShi XuanFei formula for prevention and treatment of COVID-19 based on network pharmacology and molecular docking analysis Juan WangWen GeXuyan Fu Original Article 09 June 2021 Pages: 1175 - 1190
Biomimetic hydrogenation of electron deficient olefins using in situ generated 2-arylbenzimidazoline: synthesis of novel 3-benzylbenzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones Maryam DanehchinAbbas Ali Esmaeili Original Article 11 June 2021 Pages: 1191 - 1199
New benzamide derivatives and their nicotinamide/cinnamamide analogs as cholinesterase inhibitors Mehmet KocaSinan Bilginer Original Article 24 June 2021 Pages: 1201 - 1212
Discovery, synthesis and in combo studies of Schiff’s bases as promising dipeptidyl peptidase-IV inhibitors Reema Abu KhalafMaha AwadIhsan Shabeeb Original Article 22 September 2021 Pages: 1213 - 1225
2D-QSAR modeling and two-fold classification of 1,2,4-triazole derivatives for antitubercular potency against the dormant stage of Mycobacterium tuberculosis Rahul Balasaheb AherDhiman Sarkar Original Article 04 August 2021 Pages: 1227 - 1242
Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors Maxim S. KobzevAlexander A. TitovLeonid G. Voskressensky Short Communication 04 February 2021 Pages: 1243 - 1247
Supported Cu(II)-Schiff base: novel heterogeneous catalyst with extremely high activity for eco-friendly, one-pot and multi-component C–S bond-forming reaction toward a wide range of thioethers as biologically active cores Pezhman ShiriAli Mohammad AmaniJasem Aboonajmi Short Communication 12 May 2021 Pages: 1249 - 1258
BF3-etherate promoted facile access to vinyloxyimidazopyridines: a metal-free sustainable approach Saurabh Kumar TiwariMohd NazeefI. R. Siddiqui Short Communication 16 May 2021 Pages: 1259 - 1266
Catalytic stereoselective Mannich-type reactions for construction of fluorinated compounds Minoo DabiriNoushin Farajinia LehiReza Mohammadian Comprehensive review 06 July 2021 Pages: 1267 - 1310
Catalytic and non-catalytic amidation of carboxylic acid substrates Keyvan PedroodSaeed BahadorikhaliliMohammad Mahdavi Short review 13 June 2021 Pages: 1311 - 1344
