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Catalytic and non-catalytic amidation of carboxylic acid substrates

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Abstract

The present review offers an apt summary of amide bond formation with carboxylic acid substrates by taking advantage of several methods. Carboxamides can be regarded as a substantial part of organic and medicinal chemistry due to their utility in synthesizing peptides, lactams, and more than 25% of familiar drugs. Moreover, they play a leading role in the synthesis of bioactive products with anticancer, antifungal, and antibacterial properties. The data are arranged based on the type and amount of reagents used to conduct amidation and are also divided into the following categories: catalytic amidation of carboxylic acids, non-catalytic amidation, and transamidation.

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  1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Keyvan Pedrood, Bagher Larijani & Mohammad Mahdavi

  2. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran

    Saeed Bahadorikhalili & Vahid Lotfi

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Pedrood, K., Bahadorikhalili, S., Lotfi, V. et al. Catalytic and non-catalytic amidation of carboxylic acid substrates. Mol Divers 26, 1311–1344 (2022). https://doi.org/10.1007/s11030-021-10252-0

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