1. A comprehensive regulatory and industry review of modeling and simulation practices in oncology clinical drug development

   • Ana Ruiz-Garcia
   • Paul Baverel
   • Peter Bonate

   Review Paper Open access 04 March 2023 Pages: 147 - 172

   

2. Computing optimal drug dosing with OptiDose: implementation in NONMEM

   • Freya Bachmann
   • Gilbert Koch
   • Johannes Schropp

   Original Paper 27 January 2023 Pages: 173 - 188

   

3. Pharmacokinetic comparability between two populations using nonlinear mixed effect models: a Monte Carlo study

   • Siddhee A. Sahasrabudhe
   • Peter L. Bonate

   Original Paper 28 January 2023 Pages: 189 - 201

   

4. Mechanistic inference of the metabolic rates underlying \(^{13}\)C breath test curves

   • Andrew F. Brouwer
   • Gwenyth O. Lee
   • Douglas J. Morrison

   Original Paper 15 February 2023 Pages: 203 - 214

   

5. A next generation mathematical model for the in vitro to clinical translation of T-cell engagers

   • David Flowers
   • David Bassen
   • Fei Hua

   Original Paper 15 February 2023 Pages: 215 - 227

   

6. Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules

   • Wilhelmus E. A. de Witte
   • Lindsay B. Avery
   • Maria Laura Sargentini-Maier

   Original Paper 06 March 2023 Pages: 229 - 241