Volume 48, Issue 2 | Journal of Pharmacokinetics and Pharmacodynamics

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Volume 48, Issue 2

April 2021

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11 articles in this issue

QTc interval analysis—an ever-evolving endeavor
Peter L. Bonate
Editorial 07 April 2021 Pages: 183 - 186
Detection and impact of hysteresis when evaluating a drug’s QTc effect using concentration-QTc analysis
Georg Ferber
Borje Darpo
Jiang Liu
Original Paper 28 October 2020 Pages: 187 - 202
Concentration–QTc analysis for single arm studies
Yasushi Orihashi
Shoichi Ohwada
Yuji Kumagai
Original Paper 29 January 2021 Pages: 203 - 211
PK/PD modeling of a clazosentan thorough QT study with hysteresis in concentration-QT and RR-QT
Andrea Henrich
Pierre-Eric Juif
Andreas Krause
Original Paper 02 January 2021 Pages: 213 - 224
Modeling the acute effects of exercise on glucose dynamics in healthy nondiabetic subjects
Spencer Frank
Abdulrahman Jbaily
Andrew J. Szeri
Original Paper 04 January 2021 Pages: 225 - 239
Improved numerical stability for the bounded integer model
Sebastian Ueckert
Mats O. Karlsson
Original Paper Open access 26 November 2020 Pages: 241 - 251
A pharmacodynamic model of tidal volume and inspiratory sevoflurane concentration in children during spontaneous breathing
Pyoyoon Kang
Ji-Hyun Lee
Hee-Soo Kim
Original Paper 02 January 2021 Pages: 253 - 259
Population pharmacokinetic modeling of intramuscular and oral dexamethasone and betamethasone in Indian women
Wojciech Krzyzanski
Mark A. Milad
William J. Jusko
Original Paper Open access 03 January 2021 Pages: 261 - 272
A quantitative systems pharmacological approach identified activation of JNK signaling pathway as a promising treatment strategy for refractory HER2 positive breast cancer
Yesenia L. Franco
Vidya Ramakrishnan
Sihem Ait-Oudhia
Original Paper 03 January 2021 Pages: 273 - 293
Improving priors for human monoclonal antibody linear pharmacokinetic parameters by using half-lives from non-human primates
Vittal Shivva
Martin Fink
Philip J. Lowe
Original Paper 03 January 2021 Pages: 295 - 303
Do epoch lengths of hypnotic depth indicators affect estimated of blood-brain equilibration rate constants of propofol?
Kyung Mi Kim
Sookyung Park
Ji-Yeon Bang
Original Paper 07 January 2021 Pages: 305 - 317