Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop Klaus RomeroVikram SinhaThomas Colatsky Short Report 07 October 2014 Pages: 545 - 552
Population model of longitudinal FEV1 data in asthmatics: meta-analysis and predictability of placebo response Eleonora MarosticaAlberto RussuMisba Beerahee Original Paper 15 August 2014 Pages: 553 - 569
Survey of monoclonal antibody disposition in man utilizing a minimal physiologically-based pharmacokinetic model Yanguang CaoWilliam J. Jusko Original Paper 22 August 2014 Pages: 571 - 580
An updated Alzheimer’s disease progression model: incorporating non-linearity, beta regression, and a third-level random effect in NONMEM Daniela J. ConradoWilliam S. DenneyKaori Ito Original Paper 29 August 2014 Pages: 581 - 598
Impact of aminophylline on the pharmacodynamics of propofol in beagle dogs Soo-Han LeeHyun-Ji KangGyu-Jeong Noh Original Paper 24 August 2014 Pages: 599 - 612
Computational pharmacology of rifampin in mice: an application to dose optimization with conflicting objectives in tuberculosis treatment Michael A. Lyons Original Paper 31 August 2014 Pages: 613 - 623
Continuous-time Markov modelling of flexible-dose depression trials Eleonora MarosticaAlberto RussuGiuseppe De Nicolao Original Paper 04 October 2014 Pages: 625 - 638
Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model C. Steven Ernest IIJoakim NybergAndrew C. Hooker Original Paper 12 October 2014 Pages: 639 - 654
Searching for an optimal AUC estimation method: a never-ending task? Wojciech Jawień Original Paper Open access 15 October 2014 Pages: 655 - 673
FLT3 and CDK4/6 inhibitors: Signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia Yaping ZhangCheng-Pang HsuDavid Z. D’Argenio Original Paper 19 October 2014 Pages: 675 - 691
Predicted impact of various clinical practice strategies on cardiovascular risk for the treatment of hypertension: a clinical trial simulation study Yuyan JinRobert BiesRajanikanth Madabushi Original Paper 18 October 2014 Pages: 693 - 704