1. Analysis of Nonlinear and Nonsteady State Hepatic Extraction with the Dispersion Model Using the Finite Difference Method

   • Akihiro Hisaka
   • Yuichi Sugiyama

   OriginalPaper 01 October 1998 Pages: 495 - 519

2. Quantitative Structure–Pharmacokinetics Relationships: II. A Mechanistically Based Model to Evaluate the Relationship Between Tissue Distribution Parameters and Compound Lipophilicity

   • Ivan Nestorov
   • Leon Aarons
   • Malcolm Rowland

   OriginalPaper 01 October 1998 Pages: 521 - 545

3. Pharmacokinetic–Pharmacodynamic Modeling of Tolmetin Antinociceptive Effect in the Rat Using an Indirect Response Model: A Population Approach

   • Francisco J. Flores-Murrieta
   • Hui C. Ko
   • Gilberto Castañeda-Hernández

   OriginalPaper 01 October 1998 Pages: 547 - 557

4. Integrated Pharmacokinetic–Pharmacodynamic Model for Acetaminophen, Ibuprofen, and Placebo Antipyresis in Children

   • R. Don Brown
   • Gregory L. Kearns
   • John T. Wilson

   OriginalPaper 01 October 1998 Pages: 559 - 579

5. Estimating Potency for the E _max-Model Without Attaining Maximal Effects

   • Rik C. Schoemaker
   • Joop M. A. van Gerven
   • Adam F. Cohen

   OriginalPaper 01 October 1998 Pages: 581 - 593

6. Optimal Experimental Design for Precise Estimation of the Parameters of the Axial Dispersion Model of Hepatic Elimination

   • Chen-Hsi Chou
   • Leon Aarons
   • Malcolm Rowland

   OriginalPaper 01 October 1998 Pages: 595 - 615

7. Course: Critical Issue in Tumor Microcirculation, Angiogenesis, and Metastasis: Biological Significane and Clinical Relevance

   Announcement 01 October 1998 Pages: 617 - 618