Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases Hugo GeertsSilke BergelerPiet H. van der Graaf Review Paper 28 July 2023
Correction to: Classical structural identifiability methodology applied to low-dimensional dynamic systems in receptor theory Carla WhiteVivi RottschäferLloyd Bridge Correction Open access 26 July 2023 Pages: 91 - 91
Go beyond the limits of genetic algorithm in daily covariate selection practice D. RonchiE. M. ToscaP. Magni Original Paper Open access 26 July 2023 Pages: 109 - 121
Generation and application of avatars in pharmacometric modelling Estelle ChasseloupAndrew C. HookerMats O. Karlsson Original Paper Open access 24 July 2023 Pages: 411 - 423
International society of Pharmacometrics Mentorship Program (IMP): feedback survey from the first cohort of mentor-mentee pairs Patrick O. HanafinAnanya MurthyGauri G. Rao Editorial 22 July 2023 Pages: 243 - 250
A two-stages global sensitivity analysis by using the δ sensitivity index in presence of correlated inputs: application on a tumor growth inhibition model based on the dynamic energy budget theory Alessandro De CarloElena Maria ToscaPaolo Magni OriginalPaper Open access 09 July 2023 Pages: 395 - 409
Classical structural identifiability methodology applied to low-dimensional dynamic systems in receptor theory Carla WhiteVivi RottschäferLloyd Bridge Original Paper Open access 30 June 2023 Pages: 39 - 63
Clinical validation of translational antibody PBPK model using tissue distribution data generated with 89Zr-immuno-PET imaging Shufang LiuZhe LiDhaval K. Shah Original Paper 29 June 2023 Pages: 377 - 394
Assessing the performance of QSP models: biology as the driver for validation Fulya Akpinar SinghNasrin AfzalCraig J. Thalhauser Review Paper Open access 29 June 2023
Physiologically-based pharmacokinetic modeling to predict drug-drug interaction of enzalutamide with combined P-gp and CYP3A substrates Yukio OtsukaSrinivasu PoondruTsuyoshi Minematsu Original Paper Open access 21 June 2023 Pages: 365 - 376
Challenges, approaches and enablers: effectively triangulating towards dose selection in pediatric rare diseases Chandrasekar DurairajIndranil Bhattacharya Review Paper 09 June 2023 Pages: 445 - 459
Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia Satyawan B. JadhavBenny M. AmoreMaurice G. Emery Original paper Open access 27 May 2023 Pages: 351 - 364
Empirical bayes approach for dynamic bayesian borrowing for clinical trials in rare diseases Bernard Sebastien Original Paper 06 May 2023 Pages: 495 - 499
Achieving big with small: quantitative clinical pharmacology tools for drug development in pediatric rare diseases Mariam A. AhmedJanelle BurnhamBilal AbuAsal Review Paper 04 May 2023 Pages: 429 - 444
The future of rare disease drug development: the rare disease cures accelerator data analytics platform (RDCA-DAP) Jeffrey S. BarrettAlexandre BetourneWill Roddy Review Paper Open access 02 May 2023 Pages: 507 - 519
An integrated modelling approach for targeted degradation: insights on optimization, data requirements and PKPD predictions from semi- or fully-mechanistic models and exact steady state solutions Sofia GuzzettiPablo Morentin Gutierrez Original Paper Open access 29 April 2023 Pages: 327 - 349
Special issue: Model-informed drug development in rare diseases: connecting the dots in an information rich ecosystem Rajesh Krishna Editorial 27 April 2023 Pages: 425 - 427
External control arms for rare diseases: building a body of supporting evidence Artak KhachatryanStephanie H ReadTerri Madison Review Paper Open access 24 April 2023 Pages: 501 - 506
Operational characteristics of full random effects modelling (‘frem’) compared to stepwise covariate modelling (‘scm’) Lisa F. AmannSebastian G. Wicha Original Paper Open access 21 April 2023 Pages: 315 - 326
Joint longitudinal model-based meta-analysis of FEV1 and exacerbation rate in randomized COPD trials Carolina Llanos-PaezClaire AmberyMats O. Karlsson Original Paper Open access 22 March 2023 Pages: 297 - 314
Implementation of non-linear mixed effects models defined by fractional differential equations Christos KaikousidisAristides Dokoumetzidis Original Paper Open access 21 March 2023 Pages: 283 - 295
An exploratory analysis of the performance of methylphenidate regimens based on a PKPD model of dopamine and norepinephrine transporter occupancy Sara SoufsafPhilippe RobaeyFahima Nekka Original Paper 17 March 2023 Pages: 267 - 281
Comparison of sequential and joint nonlinear mixed effects modeling of tumor kinetics and survival following Durvalumab treatment in patients with metastatic urothelial carcinoma Ting ChenYanan ZhengDonald E. Mager Original Paper 12 March 2023 Pages: 251 - 265
Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules Wilhelmus E. A. de WitteLindsay B. AveryMaria Laura Sargentini-Maier Original Paper 06 March 2023 Pages: 229 - 241
Correction to: Characterization of exposure–Clinical Dementia Rating–Sum of Boxes relationship in subjects with early Alzheimer’s disease from the aducanumab Phase 3 trials Kumar Kandadi MuralidharanKenneth G. KowalskiIvan Nestoro Correction 04 March 2023 Pages: 145 - 145
A comprehensive regulatory and industry review of modeling and simulation practices in oncology clinical drug development Ana Ruiz-GarciaPaul BaverelPeter Bonate Review Paper Open access 04 March 2023 Pages: 147 - 172
A next generation mathematical model for the in vitro to clinical translation of T-cell engagers David FlowersDavid BassenFei Hua Original Paper 15 February 2023 Pages: 215 - 227
Mechanistic inference of the metabolic rates underlying \(^{13}\)C breath test curves Andrew F. BrouwerGwenyth O. LeeDouglas J. Morrison Original Paper 15 February 2023 Pages: 203 - 214
The role of quantitative systems pharmacology in pharmacometrics and the scope of the journal Peter L. Bonate Commentary 31 January 2023 Pages: 1 - 2
Pharmacokinetic comparability between two populations using nonlinear mixed effect models: a Monte Carlo study Siddhee A. SahasrabudhePeter L. Bonate Original Paper 28 January 2023 Pages: 189 - 201
Computing optimal drug dosing with OptiDose: implementation in NONMEM Freya BachmannGilbert KochJohannes Schropp Original Paper 27 January 2023 Pages: 173 - 188
Changes in Associate Editors at the Journal of Pharmacokinetics and Pharmacodynamics Peter L. Bonate Commentary 25 January 2023 Pages: 3 - 3
Latent variable indirect response modeling of clinical efficacy endpoints with combination therapy: application to guselkumab and golimumab in patients with ulcerative colitis Chuanpu HuMarion VetterDaniele Ouellet Original Paper 17 January 2023 Pages: 133 - 144
Investigating the contribution of residual unexplained variability components on bias and imprecision of parameter estimates in population pharmacokinetic mixed-effects modeling Mutaz M. JaberRichard C. Brundage Original Paper 08 January 2023 Pages: 123 - 132
Characterization of exposure–Clinical Dementia Rating–Sum of Boxes relationship in subjects with early Alzheimer’s disease from the aducanumab Phase 3 trials Kumar Kandadi MuralidharanKenneth G. KowalskiIvan Nestorov Original Paper 04 January 2023 Pages: 45 - 62
Generative models for age, race/ethnicity, and disease state dependence of physiological determinants of drug dosing Rahul NairDeen Dayal MohanMurali Ramanathan Original Paper 24 December 2022 Pages: 111 - 122
Population pharmacokinetic and pharmacodynamic model of propofol externally validated in Korean elderly subjects Kyung Mi KimByung-Moon ChoiGyu-Jeong Noh Original Paper 16 December 2022 Pages: 97 - 109
Convolution-based approach for modeling the paliperidone extended release and Long-Acting Injectable (LAI) PK of once-, and three-monthly products administration and for optimizing the development of new LAI products Roberto GomeniFrançoise Bressolle-Gomeni Original Paper Open access 09 December 2022 Pages: 89 - 96
Two compartmental fractional derivative model with general fractional derivative Vesna Miskovic-StankovicMarko JanevTeodor M. Atanackovic Original Paper 08 December 2022 Pages: 79 - 87
A proof of concept reinforcement learning based tool for non parametric population pharmacokinetics workflow optimization J. D. OtalvaroW. M. YamadaM. N. Neely Original Paper Open access 07 December 2022 Pages: 33 - 43
Pharmacometric modeling of drug adverse effects: an application of mixture models in schizophrenia spectrum disorder patients treated with clozapine Orwa AlbitarSiti Maisharah Sheikh GhadziMaria C. Kjellsson Original Paper 15 November 2022 Pages: 21 - 31
Pharmacometric model of agalsidase–migalastat interaction in human: a novel mechanistic model of drug-drug interaction between a therapeutic protein and a small molecule Thanh BachNan WuGuohua An Original Paper 14 November 2022 Pages: 63 - 74
The Finite Absorption Time (FAT) concept en route to PBPK modeling and pharmacometrics Panos MacherasAthanasios A. Tsekouras Correspondence 11 November 2022 Pages: 5 - 10
Individualized optimization of colistin loading doses Aline Vidal Lacerda GontijoAndré V. G. Cavalieri Original Paper 02 November 2022 Pages: 11 - 20
Accelerating robust plausible virtual patient cohort generation by substituting ODE simulations with parameter space mapping Thibaud DerippeSylvain FouliardDonald E. Mager Original Paper 31 October 2022 Pages: 625 - 644
Modeling of the effect of cerebrospinal fluid flow modulation on locally delivered drugs in the brain Caroline M. WoodVeronica E. FaragJay C. Sy Original Paper 25 October 2022 Pages: 657 - 671
Physiologically-based pharmacokinetic model for pulmonary disposition of protein therapeutics in humans Prabhas JagdaleArmin SeppDhaval K. Shah Original Paper 20 October 2022 Pages: 607 - 624
A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis Feiyan LiuLinda B. S. AulinJohan G. C. van Hasselt Original Paper Open access 19 October 2022 Pages: 645 - 655