1. A Mechanism-Based Pharmacokinetic Model for the Cytochrome P450 Drug–Drug Interaction between Cyclophosphamide and ThioTEPA and the Autoinduction of Cyclophosphamide

   • Alwin D. R. Huitema
   • Ron A. A. Mathôt
   • Jos H. Beijnen

   OriginalPaper Pages: 211 - 230

2. Assessment of Actual Significance Levels for Covariate Effects in NONMEM

   • Ulrika Wählby
   • E. Niclas Jonsson
   • Mats O. Karlsson

   OriginalPaper 07 October 2004 Pages: 231 - 252

3. Efficient Screening of Covariates in Population Models Using Wald's Approximation to the Likelihood Ratio Test

   • Kenneth G. Kowalski
   • Matthew M. Hutmacher

   OriginalPaper Pages: 253 - 275

4. In Vivo–In Vitro Correlation (IVIVC) Modeling Incorporating a Convolution Step

   • T. O'Hara
   • S. Hayes
   • A. Dunne

   OriginalPaper Pages: 277 - 298

5. Population Pharmacokinetic Analysis and Optimization of the Experimental Design for Mizolastine Solution in Children

   • France Mentré
   • Catherine Dubruc
   • Jean-Paul Thénot

   OriginalPaper Pages: 299 - 319