1. Introduction: Recent Topics in the Clinical Pharmacology of Taxanes that Might Change Future Perspectives

   • Alex Sparreboom
   • Jaap Verweij

   OriginalPaper Pages: 111 - 112

2. Determinants of Paclitaxel Uptake, Accumulation and Retention in Solid Tumors

   • Seong H. Jang
   • M. Guillaume Wientjes
   • Jessie L.-S. Au

   OriginalPaper Pages: 113 - 123

3. Role of Formulation Vehicles in Taxane Pharmacology

   • Lia van Zuylen
   • Jaap Verweij
   • Alex Sparreboom

   OriginalPaper Pages: 125 - 141

4. Progress in the Development of Alternative Pharmaceutical Formulations of Taxanes

   • Bastiaan Nuijen
   • Marjan Bouma
   • Jos H. Beijnen

   OriginalPaper Pages: 143 - 153

5. Oral Delivery of Taxanes

   • Mirte M. Malingré
   • Jos H. Beijnen
   • Jan H.M. Schellens

   OriginalPaper Pages: 155 - 162

6. Population Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Relationships for Docetaxel

   • René Bruno
   • Nicole Vivier
   • Gerald R. Rhodes

   OriginalPaper Pages: 163 - 169

7. Body Surface Area as a Determinant of Pharmacokinetics and Drug Dosing

   • Michael Sawyer
   • Mark J. Ratain

   OriginalPaper Pages: 171 - 177

8. Drug Interactions of Paclitaxel and Docetaxel and their Relevance for the Design of Combination Therapy

   • Lucia Vigano
   • Alberta Locatelli
   • Luca Gianni

   OriginalPaper Pages: 179 - 196