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Neuropeptide Y and melanocortin receptors in fish: regulators of energy homeostasis

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Abstract

Energy homeostasis, which refers to the physiological processes that the energy intake is exquisitely coordinated with energy expenditure, is critical for survival. Therefore, multiple and complex mechanisms have been involved in the regulation of energy homeostasis. The central melanocortin system plays an important role in modulating energy homeostasis. This system includes the orexigenic neurons, expressing neuropeptide Y/Agouti-related protein (NPY/AgRP), and the anorexigenic neurons expressing proopiomelanocortin (POMC). The downstream receptors of NPY, AgRP and post-translational products of POMC are G protein-coupled receptors (GPCRs). This review summarizes the compelling evidence demonstrating that NPY and melanocortin receptors are involved in energy homeostasis. Subsequently, the comparative studies on physiology and pharmacology of NPY and melanocortin receptors in humans, rodents and teleosts are summarized. Also, we provide a strategy demonstrating the potential application of the new ligands and/or specific variants of melanocortin system in aquaculture.

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References

  • Arends RJ, Vermeer H, Martens GJM, Leunissen JAM, Bonga SEW, Flik G (1998) Cloning and expression of two proopiomelanocortin mRNAs in the common carp (Cyprinus carpio). Mol Cell Endocrinol 143:23–31

    Article  CAS  PubMed  Google Scholar 

  • Aspiras AC, Rohner N, Martineau B, Borowsky RL, Tabin CJ (2015) Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditions. Proc Natl Acad Sci USA 112:9668–9673

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bjarnadottir TK, Gloriam DE, Hellstrand SH, Kristiansson H, Fredriksson R, Schioth HB (2006) Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. Genomics 88:263–273

    Article  CAS  PubMed  Google Scholar 

  • Blomqvist AG, Söderberg C, Lundell I, Milner RJ, Larhammar D (1992) Strong evolutionary conservation of neuropeptide Y: sequences of chicken, goldfish, and Torpedo marmorata DNA clones. Proc Natl Acad Sci USA 89:2350–2354

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bockaert J, Pin JP (1999) Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J 18:1723–1729

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Boyce-Derricott J, Nagler JJ, Cloud JG (2009) Regulation of hepatic estrogen receptor isoform mRNA expression in rainbow trout (Oncorhynchus mykiss). Gen Comp Endocrinol 161:73–78

    Article  CAS  PubMed  Google Scholar 

  • Butler AA, Kesterson RA, Khong K, Cullen MJ, Pelleymounter MA, Dekoning J, Baetscher M, Cone RD (2000) A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141:3518–3521

    Article  CAS  PubMed  Google Scholar 

  • Butler AA, Girardet C, Mavrikaki M, Trevaskis JL, Macarthur H, Marks DL, Farr SA (2017) A life without hunger: the ups (and downs) to modulating melanocortin-3 receptor signaling. Front Neurosci 11:128

    Article  PubMed  PubMed Central  Google Scholar 

  • Cerda-Reverter JM, Schioth HB, Peter RE (2003) The central melanocortin system regulates food intake in goldfish. Regul Pept 115:101–113

    Article  CAS  PubMed  Google Scholar 

  • Cerdá-Reverter JM, Larhammar D (2000) cNeuropeptide Y family of peptides: structure, anatomical expression, function, and molecular evolution. Biochem Cell Biol 78:371–392

    PubMed  Google Scholar 

  • Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY et al (2000) Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26:97–102

    Article  CAS  PubMed  Google Scholar 

  • Chhajlani V (1996) Distribution of cDNA for melanocortin receptor subtypes in human tissues. Biochem Mol Biol Int 38:73–80

    CAS  PubMed  Google Scholar 

  • Cone RD (2005) Anatomy and regulation of the central melanocortin system. Nat Neurosci 8:571–578

    Article  CAS  PubMed  Google Scholar 

  • Cone RD (2006) Studies on the physiological functions of the melanocortin system. Endocr Rev 27:736–749

    Article  CAS  PubMed  Google Scholar 

  • de Pedro N, López-Patino MA, Guijarro AI, Pinillos ML, Delgado MJ, Alonso-Bedate M (2000) NPY receptors and opioidergic system are involved in NPY-induced feeding in goldfish. Peptides 21:1495–1502

    Article  PubMed  Google Scholar 

  • de Pedro N, Martinez-Alvarez R, Delgado MJ (2006) Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus). J Endocrinol 188:513–520

    Article  PubMed  Google Scholar 

  • Demski LS (2012) The neural control of feeding in elasmobranchs: a review and working model. Environ Biol Fishes 95:169–183

    Article  Google Scholar 

  • Dores RM, Lecaude S (2005) Trends in the evolution of the proopiomelanocortin gene. Gen Comp Endocrinol 142:81–93

    Article  CAS  PubMed  Google Scholar 

  • Dorsam RT, Gutkind JS (2007) G-protein-coupled receptors and cancer. Nat Rev Cancer 7:79–94

    Article  CAS  PubMed  Google Scholar 

  • Duarte-Neves J, de Almeida LP, Cavadas C (2016) Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases. Neurobiol Dis 95:210–224

    Article  CAS  PubMed  Google Scholar 

  • Fällmar H, Sundström G, Lundell I, Mohell N, Larhammar D (2011) Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties. Comp Biochem Phys B 160:166–173

    Article  PubMed  Google Scholar 

  • Fan ZC, Sartin JL, Tao YX (2008) Pharmacological analyses of two naturally occurring porcine melanocortin-4 receptor mutations in domestic pigs. Domest Anim Endocrinol 34:383–390

    Article  CAS  PubMed  Google Scholar 

  • Fredriksson R, Lagerstrom MC, Lundin LG, Schioth HB (2003) The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 63:1256–1272

    Article  CAS  PubMed  Google Scholar 

  • Fredriksson R, Larson ET, Yan YL, Postlethwait JH, Larhammar D (2004) Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications. J Mol Evol 58:106–114

    Article  CAS  PubMed  Google Scholar 

  • Gantz I, Fong TM (2003) The melanocortin system. Am J Physiol 284:E468–E474

    CAS  Google Scholar 

  • Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T (1993) Molecular cloning of a novel melanocortin receptor. J Biol Chem 268:8246–8250

    Article  CAS  PubMed  Google Scholar 

  • Ghamari-Langroudi M, Cakir I, Lippert RN, Sweeney P, Litt MJ, Ellacott KLJ, Cone RD (2018) Regulation of energy rheostasis by the melanocortin-3 receptor. Sci Adv 4:eaat0866

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hinney A, Volckmar AL, Knoll N (2013) Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis. Prog Mol Biol Transl 114:147–191

    Article  CAS  Google Scholar 

  • Hoegg S, Brinkmann H, Taylor JS, Meyer A (2004) Phylogenetic timing of the fish-specific genome duplication correlates with the diversification of teleost fish. J Mol Evol 59:190–203

    Article  CAS  PubMed  Google Scholar 

  • Holzer P, Reichmann F, Farzi A (2012) Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis. Neuropeptides 46:261–274

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hoskins LJ, Volkoff H (2012) The comparative endocrinology of feeding in fish: insights and challenges. Gen Comp Endocrinol 176:327–335

    Article  CAS  PubMed  Google Scholar 

  • Hughes DA, Hinney A, Brumm H, Wermter AK, Biebermann H, Hebebrand J, Stoneking M (2009) Increased constraints on MC4R during primate and human evolution. Hum Genet 124:633–647

    Article  CAS  PubMed  Google Scholar 

  • Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131–141

    Article  CAS  PubMed  Google Scholar 

  • Jegou S, Boutelet I, Vaudry H (2000) Melanocortin-3 receptor mRNA expression in pro-opiomelanocortin neurones of the rat arcuate nucleus. J Neuroendocrinol 12:501–505

    Article  CAS  PubMed  Google Scholar 

  • Kalananthan T, Lai F, Gomes AS, Murashita K, Handeland S, Rønnestad I (2020) The melanocortin system in Atlantic salmon (Salmo salar L.) and its role in appetite control. Front Neuroanat 14:48

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim KS, Larsen N, Short T, Plastow G, Rothschild MF (2000) A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm Genome 11:131–135

    Article  CAS  PubMed  Google Scholar 

  • Kim KS, Reecy JM, Hsu WH, Anderson LL, Rothschild MF (2004) Functional and phylogenetic analyses of a melanocortin-4 receptor mutation in domestic pigs. Domest Anim Endocrinol 26:75–86

    Article  CAS  PubMed  Google Scholar 

  • Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, Elmquist JK (2003) Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol 457:213–235

    Article  CAS  PubMed  Google Scholar 

  • Kitahara N, Nishizawa T, Iida K, Okazaki H, Andoh T, Soma GI (1988) Absence of a gamma-melanocyte-stimulating hormone sequence in proopiomelanocortin mRNA of chum salmon Oncorhynchus keta. Comp Biochem Physiol B 91:365–370

    Article  CAS  PubMed  Google Scholar 

  • Klovins J, Haitina T, Ringholm A, Löwgren M, Fridmanis D, Slaidina M, Stier S, Schiöth HB (2004) Cloning of two melanocortin (MC) receptors in spiny dogfish: MC3 receptor in cartilaginous fish shows high affinity to ACTH-derived peptides while it has lower preference to γ-MSH. Eur J Biochem 271:4320–4331

    Article  CAS  PubMed  Google Scholar 

  • Larhammar D (1996) Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide. Regul Pept 62:1–11

    Article  CAS  PubMed  Google Scholar 

  • Larhammar D, Wraith A, Berglund MM, Holmberg SKS, Lundell I (2001) Origins of the many NPY-family receptors in mammals. Peptides 22:295–307

    Article  CAS  PubMed  Google Scholar 

  • Larson ET, Fredriksson R, Johansson SRT, Larhammar D (2003) Cloning, pharmacology, and distribution of the neuropeptide Y-receptor Yb in rainbow trout. Peptides 24:385–395

    Article  CAS  PubMed  Google Scholar 

  • Larsson TA, Olsson F, SundstrÖm G, Brenner S, Venkatesh B, Larhammar D (2005) Pufferfish and zebrafish have five distinct NPY receptor subtypes, but have lost appetite receptors Y1 and Y5. Ann NY Acad Sci 1040:375–377

    Article  CAS  PubMed  Google Scholar 

  • Larsson A, Larson ET, Fredriksson R, Conlon JM, Larhammar D (2006) Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss. Peptides 27:1320–1327

    Article  CAS  PubMed  Google Scholar 

  • Lee YS, Poh LK, Loke KY (2002) A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity. J Clin Endocrinol Metab 87:1423–1426

    Article  CAS  PubMed  Google Scholar 

  • Li JT, Yang Z, Chen HP, Zhu CH, Deng SP, Li GL, Tao YX (2016) Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in spotted scat, Scatophagus argus. Gen Comp Endocrinol 230–231:143–152

    Article  PubMed  Google Scholar 

  • Li L, Yang Z, Zhang YP, He S, Liang XF, Tao YX (2017) Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in grass carp (Ctenopharyngodon idella). Domest Anim Endocrinol 59:140–151

    Article  CAS  PubMed  Google Scholar 

  • Logan DW, Bryson-Richardson RJ, Taylor MS, Currie P, Jackson IJ (2003a) Sequence characterization of teleost fish melanocortin receptors. Ann NY Acad Sci 994:319–330

    Article  CAS  PubMed  Google Scholar 

  • Logan DW, Bryson-Richardson RJ, Pagan KE, Taylor MS, Currie PD, Jackson IJ (2003b) The structure and evolution of the melanocortin and MCH receptors in fish and mammals. Genomics 81:184–191

    Article  CAS  PubMed  Google Scholar 

  • Lotta LA, Mokrosiński J, de Oliveira EM, Li C, Sharp SJ, Luan J, Brouwers B, Ayinampudi V, Bowker N, Kerrison N (2019) Human gain-of-function MC4R variants show signaling bias and protect against obesity. Cell 177(597–607):e599

    Google Scholar 

  • Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson DG, Statnick MA, Gadski RA, Gehlert DR, Larhammar D (1995) Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J Biol Chem 270:29123–29128

    Article  CAS  PubMed  Google Scholar 

  • Lundell I, Berglund MM, Starbäck P, Salaneck E, Gehlert DR, Larhammar D (1997) Cloning and characterization of a novel neuropeptide Y receptor subtype in the zebrafish. DNA Cell Biol 16:1357–1363

    Article  CAS  PubMed  Google Scholar 

  • Martemyanov KA, Garcia-Marcos M (2018) Making useful gadgets with miniaturized G proteins. J Biol Chem 293:7474–7475

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Matsuda K, Kang KS, Sakashita A, Yahashi S, Vaudry H (2011) Behavioral effect of neuropeptides related to feeding regulation in fish. Ann NY Acad Sci 1220:117–126

    Article  CAS  PubMed  Google Scholar 

  • Metz JR, Peters JJM, Flik G (2006) Molecular biology and physiology of the melanocortin system in fish: a review. Gen Comp Endocrinol 148:150–162

    Article  CAS  PubMed  Google Scholar 

  • Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T (1998) XVI. International union of pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev 50:143–150

    CAS  PubMed  Google Scholar 

  • Miller WE, Lefkowitz RJ (2001) Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking. Curr Opin Cell Biol 13:139–145

    Article  CAS  PubMed  Google Scholar 

  • Morton G, Cummings D, Baskin D, Barsh G, Schwartz M (2006) Central nervous system control of food intake and body weight. Nature 443:289

    Article  CAS  PubMed  Google Scholar 

  • Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD (1994) Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8:1298–1308

    CAS  PubMed  Google Scholar 

  • Narnaware YK, Peter RE (2001a) Effects of food deprivation and refeeding on neuropeptide Y (NPY) mRNA levels in goldfish. Comp Biochem Physiol B 129:633–637

    Article  CAS  PubMed  Google Scholar 

  • Narnaware YK, Peter RE (2001b) Neuropeptide Y stimulates food consumption through multiple receptors in goldfish. Physiol Behav 74:185–190

    Article  CAS  PubMed  Google Scholar 

  • Narnaware YK, Peyon PP, Lin X, Peter RE (2000) Regulation of food intake by neuropeptide Y in goldfish. Am J Physiol Regul Integr Comp Physiol 279:R1025–R1034

    Article  CAS  PubMed  Google Scholar 

  • Ni XP, Butler AA, Cone RD, Humphreys MH (2006) Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones. J Hypertens 24:2239–2246

    Article  CAS  PubMed  Google Scholar 

  • Offermanns S (2003) G-proteins as transducers in transmembrane signalling. Prog Biophys Mol Biol 83:101–130

    Article  CAS  PubMed  Google Scholar 

  • Oldham WM, Hamm HE (2008) Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol 9:60–71

    Article  CAS  PubMed  Google Scholar 

  • Rao YZ, Chen R, Zhang Y, Tao YX (2019) Orange-spotted grouper melanocortin-4 receptor: modulation of signaling by MRAP2. Gen Comp Endocrinol 284:113234

    Article  CAS  PubMed  Google Scholar 

  • Reichmann F, Holzer P (2016) Neuropeptide Y: a stressful review. Neuropeptides 55:99–109

    Article  CAS  PubMed  Google Scholar 

  • Ritter SL, Hall RA (2009) Fine-tuning of GPCR activity by receptor-interacting proteins. Nat Rev Mol Cell Biol 10:819–830

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rodrigues AR, Almeida H, Gouveia AM (2015) Intracellular signaling mechanisms of the melanocortin receptors: current state of the art. Cell Mol Life Sci 72:1331–1345

    Article  CAS  PubMed  Google Scholar 

  • Rønnestad I, Gomes AS, Murashita K, Angotzi R, Jönsson E, Volkoff H (2017) Appetite-controlling endocrine systems in teleosts. Front Endocrinol 8:73

    Article  Google Scholar 

  • Salaneck E, Fredriksson R, Larson ET, Conlon JM, Larhammar D (2001) A neuropeptide Y receptor Y1-subfamily gene from an agnathan, the European river lamprey: a potential ancestral gene. Eur J Biochem 268:6146–6154

    Article  CAS  PubMed  Google Scholar 

  • Salaneck E, Larsson TA, Larson ET, Larhammar D (2008) Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization. Gene 409:61–71

    Article  CAS  PubMed  Google Scholar 

  • Sawyer TK, Sanfilippo PJ, Hruby VJ, Engel MH, Heward CB, Burnett JB, Hadley ME (1980) 4-Norleucine, 7-D-phenylalanine-a-melanocyte-stimulating hormone: a highly potent a-melanotropin with ultralong biological activity. Proc Natl Acad Sci USA 77:5754–5758

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schjolden J, Schiöth HB, Larhammar D, Winberg S, Larson ET (2009) Melanocortin peptides affect the motivation to feed in rainbow trout (Oncorhynchus mykiss). Gen Comp Endocrinol 160:134–138

    Article  CAS  PubMed  Google Scholar 

  • Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661–671

    Article  CAS  PubMed  Google Scholar 

  • Sebhat IK, Martin WJ, Ye Z, Barakat K, Mosley RT, Johnston DB, Bakshi R, Palucki B, Weinberg DH, MacNeil T, Kalyani RN, Tang R, Stearns RA, Miller RR, Tamvakopoulos C, Strack AM, McGowan E, Cashen DE, Drisko JE, Hom GJ et al (2002) Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H–1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist. J Med Chem 45:4589–4593

    Article  CAS  PubMed  Google Scholar 

  • Sharma P, Arvidsson AK, Wraith A, Beck-Sickinger AG, Jönsson-Rylander AC, Larhammar D (1999) Characterization of the cloned Atlantic cod neuropeptide Y-Yb receptor: peptide-binding requirements distinct from known mammalian Y receptors. Gen Comp Endocrinol 115:422–428

    Article  CAS  PubMed  Google Scholar 

  • Silva AP, Xapelli S, Grouzmann E, Cavadas C (2005) The putative neuroprotective role of neuropeptide Y in the central nervous system. Curr Drug Targets CNS Neurol Disord 4:331–347

    Article  CAS  PubMed  Google Scholar 

  • Silverstein JT, Plisetskaya EM (2000) The effects of NPY and insulin on food intake regulation in fish. Am Zool 40:296–308

    CAS  Google Scholar 

  • Silverstein JT, Breininger J, Baskin DG, Plisetskaya EM (1998) Neuropeptide Y-like gene expression in the salmon brain increases with fasting. Gen Comp Endocrinol 110:157–165

    Article  CAS  PubMed  Google Scholar 

  • Smith AI, Funder JW (1988) Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr Rev 9:159–179

    Article  CAS  PubMed  Google Scholar 

  • Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C (2004) Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest 114:1158–1164

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Staubert C, Tarnow P, Brumm H, Pitra C, Gudermann T, Gruters A, Schoneberg T, Biebermann H, Rompler H (2007) Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor. Endocrinology 148:4642–4648

    Article  PubMed  Google Scholar 

  • Sundström G, Larsson TA, Xu B, Heldin J, Larhammar D (2013) Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b. Front Neurosci 7:29

    Article  PubMed  PubMed Central  Google Scholar 

  • Tao YX (2005) Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. Mol Cell Endocrinol 239:1–14

    Article  CAS  PubMed  Google Scholar 

  • Tao YX (2007) Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects. Biochim Biophys Acta 1772:1167–1174

    Article  CAS  PubMed  Google Scholar 

  • Tao YX (2008) Constitutive activation of G protein-coupled receptors and diseases: insights into mechanism of activation and therapeutics. Pharmacol Ther 120:129–148

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tao YX (2009) Mutations in melanocortin-4 receptor and human obesity. Prog Mol Biol Transl Sci 88:173–204

    Article  CAS  PubMed  Google Scholar 

  • Tao Y-X (2010) The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr Rev 31:506–543

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tao YX (2020) Molecular chaperones and G protein-coupled receptor maturation and pharmacology. Mol Cell Endocrinol 511:110862

    Article  CAS  PubMed  Google Scholar 

  • Tao YX, Segaloff DL (2004) Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation. J Clin Endocrinol Metab 89:3936–3942

    Article  CAS  PubMed  Google Scholar 

  • Tao YX, Yuan ZH, Xie J (2013) G protein-coupled receptors as regulators of energy homeostasis. Prog Mol Biol Transl Sci 114:1–43

    Article  CAS  PubMed  Google Scholar 

  • Tao M, Ji RL, Huang L, Fan SY, Liu T, Liu SJ, Tao YX (2020) Regulation of melanocortin-4 receptor pharmacology by two isoforms of melanocortin receptor accessory protein 2 in topmouth culter (Culter alburnus). Front Endocrinol 11:538

    Article  Google Scholar 

  • Tatemoto K (1982) Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci USA 79:5485–5489

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Thomsen ARB, Plouffe B, Cahill TJ III, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP (2016) GPCR-G protein-β-arrestin super-complex mediates sustained G protein signaling. Cell 166:907–919

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vaisse C, Clement K, Guy-Grand B, Froguel P (1998) A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 20:113–114

    Article  CAS  PubMed  Google Scholar 

  • van der Kraan M, Tatro JB, Entwistle ML, Brakkee JH, Burbach JP, Adan RA, Gispen WH (1999) Expression of melanocortin receptors and pro-opiomelanocortin in the rat spinal cord in relation to neurotrophic effects of melanocortins. Mol Brain Res 63:276–286

    Article  PubMed  Google Scholar 

  • Volkoff H (2016) The neuroendocrine regulation of food intake in fish: a review of current knowledge. Front Neurosci 10:540

    Article  PubMed  PubMed Central  Google Scholar 

  • Volkoff H, Canosa LF, Unniappan S, Cerda-Reverter JM, Bernier NJ, Kelly SP, Peter RE (2005) Neuropeptides and the control of food intake in fish. Gen Comp Endocrinol 142:3–19

    Article  CAS  PubMed  Google Scholar 

  • Wang F, Chen W, Lin H, Li WJ (2014) Cloning, expression, and ligand-binding characterization of two neuropeptide Y receptor subtypes in orange-spotted grouper, Epinephelus coioides. Fish Physiol Biochem 40:1693–1707

    Article  CAS  PubMed  Google Scholar 

  • Wang T, Liang J, Xiang X, Chen X, Zhang B, Zhou N, Huang W, Yang J (2019) Pharmacological characterization, cellular localization and expression profile of NPY receptor subtypes Y2 and Y7 in large yellow croaker, Larimichthys crocea. Comp Biochem Physiol B 238:110347

    Article  CAS  PubMed  Google Scholar 

  • Wei R, Yuan D, Zhou C, Wang T, Lin F, Chen H, Wu H, Xin Z, Yang S, Chen D, Wang Y, Liu J, Gao Y, Li Z (2013) Cloning, distribution and effects of fasting status of melanocortin 4 receptor (MC4R) in Schizothorax prenanti. Gene 532:100–107

    Article  CAS  PubMed  Google Scholar 

  • Won ET, Borski RJ (2013) Endocrine regulation of compensatory growth in fish. Front Endocrinol 4:74

    Article  Google Scholar 

  • Yang H, Yang L (2016) Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy. J Mol Endocrinol 57:R93–R108

    Article  CAS  PubMed  Google Scholar 

  • Yang LK, Zhang ZR, Wen HS, Tao YX (2019) Characterization of channel catfish (Ictalurus punctatus) melanocortin-3 receptor reveals a potential network in regulation of energy homeostasis. Gen Comp Endocrinol 277:90–103

    Article  CAS  PubMed  Google Scholar 

  • Yang Z, Liang XF, Li GL, Tao YX (2020) Biased signaling in fish melanocortin-4 receptors (MC4Rs): Divergent pharmacology of four ligands on spotted scat (Scatophagus argus) and grass carp (Ctenopharyngodon idella) MC4Rs. Mol Cell Endocrinol 515:110929

    Article  CAS  PubMed  Google Scholar 

  • Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O’Rahilly S (1998) A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 20:111–112

    Article  CAS  PubMed  Google Scholar 

  • Yi TL, Yang LK, Ruan GL, Yang DQ, Tao YX (2018) Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology. Gene 678:79–89

    Article  CAS  PubMed  Google Scholar 

  • Zhang KQ, Hou ZS, Wen HS, Li Y, Qi X, Li WJ, Tao YX (2019) Melanocortin-4 receptor in spotted sea bass, Lateolabrax maculatus: cloning, tissue distribution, physiology, and pharmacology. Front Endocrinol 10:705

    Article  Google Scholar 

  • Zhang Y, Wen HS, Li Y, Lyu LK, Zhang ZX, Wang XJ, Li JS, Tao YX, Qi X (2020) Melanocortin-4 receptor regulation of reproductive function in black rockfish (Sebastes schlegelii). Gene 741:144541

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

Research in the authors’ laboratories was supported by grants from Blue Granary Science and Technology Innovation [2019YFD0901000].

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Authors and Affiliations

  1. Key Laboratory of Mariculture (Ocean University of China), Ministry of Education (KLMME), Fisheries College, Ocean University of China, Qingdao, 266003, China

    Zhi-Shuai Hou & Hai-Shen Wen

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  1. Zhi-Shuai Hou
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  2. Hai-Shen Wen
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Contributions

Conceptualization: HW and ZH; visualization: HW and ZH; writing-original draft: HW and ZH; writing-review and editing: HW and ZH.

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Correspondence to Hai-Shen Wen.

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The authors declare that they have no conflict of interest.

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Animal and human studies are not involved in this review paper.

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Edited by Xin Yu.

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Hou, ZS., Wen, HS. Neuropeptide Y and melanocortin receptors in fish: regulators of energy homeostasis. Mar Life Sci Technol 4, 42–51 (2022). https://doi.org/10.1007/s42995-021-00106-x

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  • DOI: https://doi.org/10.1007/s42995-021-00106-x

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