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Tartaric Acid: A Naturally Green and Efficient Di-Functional Brønsted Acid Catalyst for the One-Pot Four-Component Synthesis of Polysubstituted Dihydropyrrol-2-Ones at Ambient Temperature

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Abstract

A series of biologically active polysubstituted dihydropyrrol-2-ones are prepared via a one-pot four-component reaction of structurally diverse dialkyl acetylenedicarboxylate, formaldehyde, and amines (aromatic and aliphatic) using a catalytic amount of tartaric acid as a naturally green, mild di-functional Brønsted acid catalyst at ambient temperature. The use of tartaric acid as an inexpensive catalyst makes this procedure eco-friendlier and also one-pot, easily separated from the reaction mixture, good to high yields, short reaction times, simple operational procedures, and highly efficient that are the added advantages of the present methodology.

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Acknowledgments

We gratefully acknowledge financial support from the research council of the university of Sistan and Baluchestan.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran

    Farzaneh Mohamadpour, Malek Taher Maghsoodlou & Reza Heydari

  2. Faculty of Science, Velayat University, Iranshahr, Iran

    Mojtaba Lashkari

Authors
  1. Farzaneh Mohamadpour
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  2. Malek Taher Maghsoodlou
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  3. Reza Heydari
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  4. Mojtaba Lashkari
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Correspondence to Malek Taher Maghsoodlou.

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Mohamadpour, F., Maghsoodlou, M.T., Heydari, R. et al. Tartaric Acid: A Naturally Green and Efficient Di-Functional Brønsted Acid Catalyst for the One-Pot Four-Component Synthesis of Polysubstituted Dihydropyrrol-2-Ones at Ambient Temperature. Iran J Sci Technol Trans Sci 41, 843–849 (2017). https://doi.org/10.1007/s40995-016-0049-0

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  • DOI: https://doi.org/10.1007/s40995-016-0049-0

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