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Tartaric acid: a natural, green and highly efficient catalyst for the one-pot synthesis of functionalized piperidines

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Abstract

Tartaric acid is a highly effective and efficient catalyst for the one-pot synthesis of highly substituted piperidines through a combination of 1,3-dicarbonyl compounds, aromatic aldehydes, and various amines in methanol at room temperature. The advantages of this protocol are good yields, short reaction time, mild reaction conditions, no need for column chromatography, easy access, simple work-up procedure, and a cheap and biodegradable catalyst.

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Acknowledgment

We gratefully acknowledge financial support from the Research Council of University of Sistan and Baluchestan, Iran.

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Authors and Affiliations

  1. Department of Chemistry, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran

    Jasem Aboonajmi, Malek Taher Maghsoodlou, Nourallah Hazeri & Mehrnoosh Kangani

  2. Faculty of Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Esfahan, Iran

    Mojtaba Lashkari

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  1. Jasem Aboonajmi
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  2. Malek Taher Maghsoodlou
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Correspondence to Malek Taher Maghsoodlou.

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Aboonajmi, J., Maghsoodlou, M.T., Hazeri, N. et al. Tartaric acid: a natural, green and highly efficient catalyst for the one-pot synthesis of functionalized piperidines. Res Chem Intermed 41, 8057–8065 (2015). https://doi.org/10.1007/s11164-014-1877-1

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